Eggermont J J, Schmidt P H
Ann Otol Rhinol Laryngol. 1985 Jan-Feb;94(1 Pt 1):1-9. doi: 10.1177/000348948509400101.
Twenty patients suffering from Meniere's disease or Lermoyez syndrome were studied with respect to the time course of their hearing loss. Careful history-taking as well as repeated audiometry over long time spans (5-20 years) resulted in a longitudinal study of hearing loss at the standard audiometric frequencies. From these time series, correlation coefficients were computed between the changes in both ears at identical frequencies, and for changes in the same ear at different frequencies. Correlations between changes in hearing loss in both ears were more obvious in bilateral Meniere's disease than in unilateral disease. Correlations between changes in hearing loss at different frequencies were also more pronounced in Meniere's disease ears than in normal ears. If was found that recovery of hearing loss after an attack was nearly identical each time it occurred in the same ear, but differed between ears and patients. This deterministic finding in the otherwise random course of the hearing loss as a function of time may be important in deciding what mechanisms cause fluctuating hearing loss in Meniere's disease.
对20名患有梅尼埃病或勒莫耶综合征的患者的听力损失时间进程进行了研究。通过仔细的病史采集以及长时间跨度（5至20年）的反复听力测定，对标准听力测定频率下的听力损失进行了纵向研究。从这些时间序列中，计算了相同频率下双耳变化之间以及同一耳不同频率变化之间的相关系数。双耳听力损失变化之间的相关性在双侧梅尼埃病中比在单侧疾病中更明显。不同频率下听力损失变化之间的相关性在梅尼埃病耳中也比在正常耳中更显著。研究发现，同一只耳朵每次发作后听力损失的恢复情况几乎相同，但不同耳朵和患者之间存在差异。在听力损失随时间的随机过程中这一确定性发现，对于确定导致梅尼埃病波动性听力损失的机制可能很重要。
