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S100A11是一种潜在的预后生物标志物，与胶质瘤中的肿瘤免疫抑制微环境相关。

S100A11 is a potential prognostic biomarker and correlated with tumor immunosuppressive microenvironment in glioma.

作者信息

Fan Jikang, Wang Xuya, Yang Xuejun

机构信息

Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.

Laboratory of Neuro-oncology, Tianjin Neurological Institute, Tianjin, China.

出版信息

Medicine (Baltimore). 2024 Dec 20;103(51):e40701. doi: 10.1097/MD.0000000000040701.

DOI:10.1097/MD.0000000000040701
PMID:39705426
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11666167/
Abstract

BACKGROUND

This study investigates the role of S100A11 as a potential biomarker for glioma-associated macrophages (GAMs) and its correlation with GAMs infiltration in glioblastoma multiforme, aiming to better understand the immune microenvironment of glioma.

METHODS

We conducted a comprehensive study using various techniques and approaches. First, we examined the expression of S100A11 on GAMs through Western blot, immunohistochemistry, and immunofluorescence analyses. Additionally, we utilized single-cell sequencing data and immune infiltration analysis to establish the relationship between S100A11 and GAMs infiltration in glioma.

RESULTS

Our findings revealed that S100A11 was highly expressed on GAMs, as validated by Western blot, immunohistochemistry, and immunofluorescence. Moreover, S100A11 exhibited a strong correlation with GAMs infiltration, as evidenced by single-cell data and immune infiltration analysis. These results highlight the significant association of S100A11 with the immune microenvironment surrounding glioma.

CONCLUSION

S100A11 emerges as a promising candidate for regulating glioma immunosuppression and may serve as a potential marker for GAMs. This study sheds light on the crucial role of S100A11 in the crosstalk between GAMs and glioma cells, contributing to our understanding of glioma progression within the tumor microenvironment.

摘要

背景

本研究调查了S100A11作为胶质瘤相关巨噬细胞（GAMs）潜在生物标志物的作用及其与多形性胶质母细胞瘤中GAMs浸润的相关性，旨在更好地了解胶质瘤的免疫微环境。

方法

我们使用各种技术和方法进行了一项综合研究。首先，我们通过蛋白质免疫印迹、免疫组织化学和免疫荧光分析检测了GAMs上S100A11的表达。此外，我们利用单细胞测序数据和免疫浸润分析来建立S100A11与胶质瘤中GAMs浸润之间的关系。

结果

我们的研究结果表明，通过蛋白质免疫印迹、免疫组织化学和免疫荧光验证，S100A11在GAMs上高度表达。此外，单细胞数据和免疫浸润分析表明，S100A11与GAMs浸润呈强相关。这些结果突出了S100A11与胶质瘤周围免疫微环境的显著关联。

结论

S100A11成为调节胶质瘤免疫抑制的有希望的候选者，并可能作为GAMs的潜在标志物。本研究揭示了S100A11在GAMs与胶质瘤细胞相互作用中的关键作用，有助于我们了解肿瘤微环境中胶质瘤的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/1006342b9266/medi-103-e40701-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/51ef555a61af/medi-103-e40701-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/d975b110afff/medi-103-e40701-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/4cdd6b903134/medi-103-e40701-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/b58bf33120c5/medi-103-e40701-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/77455ce1580f/medi-103-e40701-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/cfa0f6e4d0aa/medi-103-e40701-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/14fc8434e8ca/medi-103-e40701-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/1006342b9266/medi-103-e40701-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/51ef555a61af/medi-103-e40701-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/d975b110afff/medi-103-e40701-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/4cdd6b903134/medi-103-e40701-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/b58bf33120c5/medi-103-e40701-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/77455ce1580f/medi-103-e40701-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/cfa0f6e4d0aa/medi-103-e40701-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/14fc8434e8ca/medi-103-e40701-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3353/11666167/1006342b9266/medi-103-e40701-g008.jpg

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