Chen Jianan, Wu Qiong, Berglund Anders E, Macaulay Robert J, Etame Arnold B
Department of Neuro-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Cells. 2025 Jan 7;14(2):66. doi: 10.3390/cells14020066.
Glioblastoma (GBM) is a highly aggressive brain tumor characterized by its ability to evade the immune system, hindering the efficacy of current immunotherapies. Recent research has highlighted the important role of immunosuppressive macrophages in the tumor microenvironment (TME) in driving this immune evasion. In this study, we are the first to identify as a key regulator of tumor-associated macrophage (TAM)-mediated immunosuppression in GBM. We found that a high expression is associated with poor patient outcomes and increased infiltration of immune cells, particularly macrophages. Functional analyses revealed 's critical involvement in immune-related pathways, including immune response activation, mononuclear cell differentiation, and the positive regulation of cytokine production. Additionally, single-cell RNA sequencing data demonstrated that macrophages with a high expression were associated with increased phagocytosis, immune suppression, and enhanced tumor growth. These findings suggest that could serve as both a prognostic marker and a therapeutic target for enhancing anti-tumor immunity in GBM.
胶质母细胞瘤（GBM）是一种极具侵袭性的脑肿瘤，其特点是能够逃避免疫系统，从而阻碍了当前免疫疗法的疗效。最近的研究强调了免疫抑制性巨噬细胞在肿瘤微环境（TME）中推动这种免疫逃逸的重要作用。在本研究中，我们首次确定[具体物质名称未给出]是胶质母细胞瘤中肿瘤相关巨噬细胞（TAM）介导的免疫抑制的关键调节因子。我们发现高[具体物质名称未给出]表达与患者预后不良以及免疫细胞尤其是巨噬细胞浸润增加有关。功能分析表明[具体物质名称未给出]在免疫相关途径中起关键作用，包括免疫反应激活、单核细胞分化以及细胞因子产生的正调控。此外，单细胞RNA测序数据表明，高[具体物质名称未给出]表达的巨噬细胞与吞噬作用增加、免疫抑制和肿瘤生长增强有关。这些发现表明，[具体物质名称未给出]既可以作为预后标志物，也可以作为增强胶质母细胞瘤抗肿瘤免疫力的治疗靶点。
