Campanale R P, Frey C F, Farias L R, Twomey P L, Guernsey J M, Keehn R, Higgins G
Arch Surg. 1985 Mar;120(3):283-8. doi: 10.1001/archsurg.1985.01390270023005.
A collaborative Veterans Administration and University of California, Davis Medical Center group of 586 patients with histologically proved pancreatic carcinoma was reviewed. During laparotomy, 159 patients underwent 251 frozen-section pancreatic biopsies with subsequent permanent section examination of the same tissue block. All 112 positive frozen-section diagnoses were corroborated on permanent sectioning. The 47 patients with false-negative biopsy specimens were equally divided between sampling and interpretation error. We conclude that in this group of 159 pancreatic cancer patients, 30% failed to be correctly diagnosed by intraoperative frozen-section biopsy. This failure was due to patient sampling and interpretation error in equal proportion. Interpretation error rates were not influenced by the type or number of biopsies. Patient sampling error is apparently reduced by repeated biopsy, and specimen sampling error occurred less frequently with wedge biopsy.
对退伍军人管理局和加利福尼亚大学戴维斯分校医学中心合作的一组586例经组织学证实的胰腺癌患者进行了回顾性研究。在剖腹手术期间，159例患者接受了251次胰腺冰冻切片活检，随后对同一组织块进行了永久切片检查。所有112例冰冻切片阳性诊断在永久切片时均得到证实。47例活检标本为假阴性的患者在取材和判读错误方面比例相等。我们得出结论，在这组159例胰腺癌患者中，30%未能通过术中冰冻切片活检得到正确诊断。这种失败是由于取材和判读错误的比例相等。判读错误率不受活检类型或数量的影响。重复活检显然可减少取材误差，楔形活检标本取材误差的发生频率较低。
