Harris P L, Rumley T O, Lineaweaver W C, Copeland E M
South Med J. 1985 Sep;78(9):1053-6. doi: 10.1097/00007611-198509000-00007.
Thirty-two patients with a resectable mass in the head of the pancreas had pancreaticoduodenectomy for suspected or proven cancer. Twenty-eight proved to have cancer (15 periampullary and 13 pancreatic), and four had pancreatitis. The five-year survival for periampullary and pancreatic cancer was 25% and 0%, respectively. The operative mortality was 19%. There were no false-positive frozen section diagnoses. Seventy-five percent with negative frozen section proved to have cancer, of which 17% were five-year survivors. Surgical judgment based on clinical findings may be more reliable than a negative frozen section in the diagnosis of suspected malignancy. Pancreaticoduodenectomy can be done on the basis of clinical judgment when no tumor is seen on frozen section of a mass in the head of the pancreas.
32例胰头可切除性肿块患者因怀疑或确诊为癌症接受了胰十二指肠切除术。28例确诊为癌症（15例为壶腹周围癌，13例为胰腺癌），4例为胰腺炎。壶腹周围癌和胰腺癌的五年生存率分别为25%和0%。手术死亡率为19%。未出现冰冻切片假阳性诊断。冰冻切片阴性的患者中，75%最终确诊为癌症，其中17%为五年生存者。在疑似恶性肿瘤的诊断中，基于临床发现的手术判断可能比冰冻切片阴性结果更可靠。当胰腺头部肿块的冰冻切片未见肿瘤时，可根据临床判断进行胰十二指肠切除术。
