Valencia G, Burgues P, Reig F, Garcia Anton J M, Alsina M A
Biochem Biophys Res Commun. 1985 Jan 16;126(1):269-74. doi: 10.1016/0006-291x(85)90601-1.
Monomolecular films of lecithin, gangliosides or lecithin/gangliosides mixtures were studied on a Langmuir through in order to examine the interactions between these lipids and opioid agonists or antagonists. Lecithin alone did not interact in a monolayer structure with opioids. However, gangliosides and lecithin/gangliosides mixtures were expanded by both morphine and naloxone. The expansion of ganglioside-containing monolayers was greater with morphine than with the antagonist, naloxone.
为了研究卵磷脂、神经节苷脂或卵磷脂/神经节苷脂混合物与阿片类激动剂或拮抗剂之间的相互作用，在Langmuir槽上对它们的单分子膜进行了研究。单独的卵磷脂在单层结构中不与阿片类药物相互作用。然而，神经节苷脂以及卵磷脂/神经节苷脂混合物都会被吗啡和纳洛酮扩张。含神经节苷脂的单分子层被吗啡扩张的程度比被拮抗剂纳洛酮扩张的程度更大。
