生殖因素与上皮性卵巢癌风险：亚洲队列联盟的研究结果
Reproductive factors and risk of epithelial ovarian cancer: results from the Asia Cohort Consortium.
作者信息
Merritt Melissa A, Abe Sarah Krull, Islam Md Rashedul, Rahman Md Shafiur, Saito Eiko, Katagiri Ryoko, Shin Aesun, Choi Ji-Yeob, Le Marchand Loïc, Killeen Jeffrey L, Gao Yu-Tang, Tamakoshi Akiko, Koh Woon-Puay, Sakata Ritsu, Sawada Norie, Tsuji Ichiro, Sugawara Yumi, Kim Jeongseon, Park Sue K, Kweon Sun-Seog, Shu Xiao-Ou, Kimura Takashi, Yuan Jian-Min, Tsugane Shoichiro, Kanemura Seiki, Lu Yukai, Shin Min-Ho, Wen Wanqing, Ahsan Habibul, Boffetta Paolo, Chia Kee Seng, Matsuo Keitaro, Qiao You-Lin, Rothman Nathaniel, Zheng Wei, Inoue Manami, Kang Daehee
机构信息
The Daffodil Centre, The University of Sydney, A Joint Venture with Cancer Council New South Wales, Sydney, NSW, Australia.
Division of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
出版信息
Br J Cancer. 2025 Mar;132(4):361-370. doi: 10.1038/s41416-024-02924-z. Epub 2024 Dec 20.
BACKGROUND
There are scarce data on risk factors for epithelial ovarian cancer (EOC) in Asian populations. Our goal was to advance knowledge on reproductive -related risk factors for EOC in a large population of Asian women.
METHODS
This study used pooled individual data from baseline questionnaires in 11 prospective cohorts (baseline years, 1958-2015) in the Asia Cohort Consortium. A Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusting for age, parity and cohort.
RESULTS
After a mean = 17.0 years (SD = 6.3) of follow-up, 674 incident invasive EOC cases were identified among 325,626 women. In multivariable adjusted models we observed an inverse association with parity (5+ children vs. 0, HR = 0.44, 95% CI = 0.28-0.68, Ptrend < 0.001), and a positive association with increasing menopausal age (55+ years vs. <45, HR = 1.77, 95% CI = 1.05-3.01, Ptrend = 0.02) for risk of all EOC.
CONCLUSIONS
In this large study of Asian women we identified an inverse association with parity and a positive association with higher menopausal age in relation to EOC risk. Further work is needed to understand EOC risk factors for rare histologic subtypes that occur more frequently in Asian populations.
背景
关于亚洲人群上皮性卵巢癌（EOC）危险因素的数据稀缺。我们的目标是增进对大量亚洲女性中与EOC生殖相关危险因素的了解。
方法
本研究使用了亚洲队列联盟中11个前瞻性队列（基线年份，1958 - 2015年）基线问卷的汇总个体数据。采用Cox比例风险回归模型来估计风险比（HRs）和95%置信区间（CIs），并对年龄、产次和队列进行了调整。
结果
在平均随访17.0年（标准差 = 6.3）后，在325,626名女性中确定了674例侵袭性EOC病例。在多变量调整模型中，我们观察到所有EOC风险与产次呈负相关（5个及以上孩子与0个孩子相比，HR = 0.44，95% CI = 0.28 - 0.68，Ptrend < 0.001），与绝经年龄增加呈正相关（55岁及以上与45岁以下相比，HR = 1.77，95% CI = 1.05 - 3.01，Ptrend = 0.02）。
结论
在这项针对亚洲女性的大型研究中，我们确定了EOC风险与产次呈负相关，与较高的绝经年龄呈正相关。需要进一步开展工作以了解在亚洲人群中更常见的罕见组织学亚型的EOC危险因素。
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