Li Dong, Sun Jingchao, Qi Chao, Fu Xifeng, Gao Fei
Department of Biliary and Pancreatic Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, No. 99, Longcheng Street, Xiaodian, Taiyuan, 030032, China.
BMC Gastroenterol. 2024 Dec 20;24(1):468. doi: 10.1186/s12876-024-03560-w.
The indicators for rapid assessment of the severity of acute cholangitis remain highly debated. Therefore, this study aimed to evaluate the efficacy of various inflammatory and immune-nutritional markers in predicting the severity of acute cholangitis. The prognostic roles of the following markers were investigated: Systemic Immune-Inflammatory Index (SII), Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), Albumin (Alb), and Prognostic Nutritional Index (PNI). A total of 139 patients with acute cholangitis were included in the study. The inflammatory and immune-nutritional markers with better predictive efficacy were selected to construct a combined predictive score. According to the survival ROC curve analysis, the combined NLR and PNI score, termed PNS, demonstrated the best prognostic performance with an AUC of 0.853. Multivariable survival analysis identified the following independent prognostic factors: PNS (p = 0.010) and Prothrombin Time (PT) (p = 0.003). The results indicate that PNS = 2 is associated with a higher incidence of severe cholangitis.
急性胆管炎严重程度快速评估的指标仍存在高度争议。因此，本研究旨在评估各种炎症和免疫营养标志物在预测急性胆管炎严重程度方面的效能。研究了以下标志物的预后作用：全身免疫炎症指数（SII）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、白蛋白（Alb）和预后营养指数（PNI）。本研究共纳入139例急性胆管炎患者。选择预测效能较好的炎症和免疫营养标志物构建联合预测评分。根据生存ROC曲线分析，联合NLR和PNI评分（称为PNS）显示出最佳的预后性能，AUC为0.853。多变量生存分析确定了以下独立预后因素：PNS（p = 0.010）和凝血酶原时间（PT）（p = 0.003）。结果表明，PNS = 2与严重胆管炎的较高发生率相关。
