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内镜下乳头大球囊扩张术联合或不联合内镜下括约肌切开术治疗胆总管结石

Endoscopic Papillary Large Balloon Dilatation With or Without Endoscopic Sphincterotomy in the Treatment of Common Bile Duct Stones.

作者信息

Wang Jia, Cao Lichao, Xue Kuijin, Qi Peng, Mao Qingdong, Cui Mingjuan, Ju Hui, He Baoguo, Cao Bin

机构信息

Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, Shandong Province, China.

Health Care Management Master of Science, Johns Hopkins University, Baltimore, MD, USA.

出版信息

Dig Dis Sci. 2025 Feb;70(2):478-493. doi: 10.1007/s10620-024-08797-9. Epub 2024 Dec 21.

Abstract

PURPOSE OF REVIEW

Endoscopic papillary large balloon dilation (EPLBD) has been proved to have better efficacy and safety in removing common bile duct stones. Conventional endoscopic sphincterotomy (EST) is usually performed before EPLBD. However, EPLBD without EST has recently reported short-term outcomes similar to those of EPLBD with EST. This article summarizes the latest research advances in EPLBD with or without EST for the treatment of large common bile duct stones (CBDS) as a way to provide further evidence to support the ERCP surgeon's choice of which technique to use for the treatment of large CBDS.

FINDINGS

EPLBD alone is recommended in cases of anatomical abnormalities or bleeding tendencies. EPLBD with EST is recommended in patients with stenosis of the duodenal papilla or distal common bile duct or with periportal diverticula. Most clinical studies have shown that the clinical efficacy and incidence of adverse events associated with ESLBD are comparable to those of standalone EPLBD. However, further large-scale prospective randomized controlled trials are needed to confirm these findings.

摘要

综述目的

内镜乳头大球囊扩张术(EPLBD)已被证明在清除胆总管结石方面具有更好的疗效和安全性。传统的内镜括约肌切开术(EST)通常在EPLBD之前进行。然而,最近有报道称,不进行EST的EPLBD的短期疗效与进行EST的EPLBD相似。本文总结了有或无EST的EPLBD治疗胆总管大结石(CBDS)的最新研究进展,以便为内镜逆行胰胆管造影(ERCP)外科医生选择治疗胆总管大结石的技术提供进一步的证据支持。

研究结果

对于存在解剖异常或出血倾向的病例,建议单独使用EPLBD。对于十二指肠乳头或胆总管远端狭窄或伴有门静脉周围憩室的患者,建议进行EPLBD联合EST。大多数临床研究表明,ESLBD的临床疗效和不良事件发生率与单独的EPLBD相当。然而,需要进一步的大规模前瞻性随机对照试验来证实这些发现。

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