May S J, Smith S A, Jacobs A, Williams A, Bailey-Wood R
Br J Haematol. 1985 Feb;59(2):311-9. doi: 10.1111/j.1365-2141.1985.tb02996.x.
A detailed study of 43 newly diagnosed cases of myelodysplastic syndrome (MDS) shows that many of the morphological features of blood and bone marrow are common to the different FAB groups. In addition, there is no clear distinction between the groups with regard to CFU-E, BFU-E or CFU-GM colony growth in vitro or ferrokinetic assessment of erythropoiesis in vivo. The interrelationships between all the parameters we have studied have been examined and there is little correlation between erythroid colony formation in vitro, the percentage erythroblasts in the bone marrow, erythroid output measured by ferrokinetics and the peripheral blood reticulocyte count, all of which appear to measure different aspects of erythropoiesis. Reduced erythroid colony growth and a high degree of ineffective erythropoiesis in vivo are common in all groups and appear to be an early manifestation of abnormal function. Decreasing marrow iron turnover is more closely related to increasing numbers of marrow blast cells than any other index of erythropoiesis.
一项对43例新诊断的骨髓增生异常综合征（MDS）病例的详细研究表明，血液和骨髓的许多形态学特征在不同的FAB组中是常见的。此外，在体外CFU-E、BFU-E或CFU-GM集落生长或体内红细胞生成的铁动力学评估方面，各组之间没有明显区别。我们研究的所有参数之间的相互关系都已进行了检查，体外红系集落形成、骨髓中早幼红细胞百分比、通过铁动力学测量的红系输出以及外周血网织红细胞计数之间几乎没有相关性，所有这些似乎都在测量红细胞生成的不同方面。所有组中普遍存在红系集落生长减少和体内高度无效的红细胞生成，这似乎是功能异常的早期表现。骨髓铁周转率的降低与骨髓原始细胞数量的增加比任何其他红细胞生成指标的关系更为密切。
