Howarth J E, Waters H M, Hyde K, Shanks D, Geary C G
University Department of Clinical Haematology, Manchester Royal Infirmary.
J Clin Pathol. 1991 May;44(5):395-9. doi: 10.1136/jcp.44.5.395.
Erythrokinetic studies were performed on 10 patients with chronic myelofibrosis and 11 patients with myelodysplasia (MDS). Values for plasma iron turnover, marrow iron turnover, and erythron transferrin uptake were derived using two ferrokinetic models. One entailed analysis of the extended plasma iron clearance over a number of days, the other comprised analysis of the initial plasma iron clearance during the first few hours of the study. A close correlation was found between the variables quantifying total erythropoiesis (marrow iron turnover and erythron transferrin uptake) in the two methodologies. Functional classifications produced by both models and based on the values for plasma iron turnover, marrow iron turnover, and erythron transferrin uptake were compared. Both models identified functional heterogeneity in the group with myelofibrosis and functional homogeneity within the MDS group. Each method produced comparable data on erythropoiesis. The main reason for analysing the extended plasma iron clearance is to differentiate levels of effective and ineffective erythropoiesis. The short analysis presents the practical advantages associated with a one-day study. This could be further enhanced if the level of effective erythropoiesis could be clearly defined.
对10例慢性骨髓纤维化患者和11例骨髓增生异常综合征（MDS）患者进行了红细胞动力学研究。使用两种铁动力学模型得出血浆铁周转率、骨髓铁周转率和红细胞系转铁蛋白摄取值。一种方法是对数天内的延长血浆铁清除率进行分析，另一种方法是对研究最初几小时内的初始血浆铁清除率进行分析。在两种方法中，量化总红细胞生成的变量（骨髓铁周转率和红细胞系转铁蛋白摄取）之间发现了密切相关性。比较了两种模型基于血浆铁周转率、骨髓铁周转率和红细胞系转铁蛋白摄取值得出的功能分类。两种模型均识别出骨髓纤维化组中的功能异质性以及MDS组内的功能同质性。每种方法得出的关于红细胞生成的数据具有可比性。分析延长血浆铁清除率的主要原因是区分有效和无效红细胞生成的水平。短时间分析具有一日研究的实际优势。如果能明确界定有效红细胞生成水平，这一优势还可进一步增强。
