Khachatrian H T, Matnishian A A, Magakian Y A
Biochim Biophys Acta. 1985 Mar 20;824(3):243-6. doi: 10.1016/0167-4781(85)90054-5.
Lowering magnesium concentration below the value of 1 mM leads to a structural transition of chicken erythrocyte chromatin in situ, which results in a change in its fragmentation by pancreatic DNAase (DNAase I) from double-nucleosome to 100-basepairs mode. At 0.75 mM MgCl2, the pattern of chromatin fragmentation by DNAase I is similar to that generated by DNAase II, and it is further changed at lower concentrations of magnesium. This transition is, at least partly, reversible, and is, presumably, related to packing of the 25-30 nm chromatin fiber into higher-order structures.
将镁离子浓度降至1 mM以下会导致鸡红细胞染色质在原位发生结构转变，这会使其被胰腺DNA酶（DNA酶I）切割的片段化模式从双核小体模式转变为100碱基对模式。在0.75 mM MgCl₂ 时，DNA酶I切割染色质的模式类似于DNA酶II产生的模式，并且在更低的镁离子浓度下会进一步改变。这种转变至少部分是可逆的，并且可能与25 - 30 nm染色质纤维包装成更高层次结构有关。
