Darwish Moshera H, El-Tamawy Mohammed S, Ismail Manar E, Moustafa Engy BadrEldin S, Khalifa Heba A
Department of Physical Therapy for Neurology and Neurosurgery, Faculty for Physical Therapy, Cairo University, 12612, Egypt.
Department of Neurology, Faculty of Medicine, Cairo University, Egypt.
Mult Scler Relat Disord. 2025 Jan;93:106239. doi: 10.1016/j.msard.2024.106239. Epub 2024 Dec 18.
Cognitive dysfunction is prevalent but inadequately treated in people with multiple sclerosis (PwMS). Central vestibular functions are associated with multiple cognitive domains in PwMS, even when controlling for disability status. To our knowledge, the effectiveness of vestibular training on cognition in PwMS has never been explored. The study's purpose was to determine the effect of vestibular training on PwMS's cognitive functions.
Forty PwMS with relapsing-remitting MS, primarily fatigued, were randomly divided into two equal groups. The control group (GI) was treated with aerobic endurance exercises using stationary bicycle training. The study group (GII) was treated with aerobic endurance exercises as GI in addition to a designed vestibular training program. Outcome measures of cognition were assessed pre- and post-treatment using the Arabic version of Brief International Cognitive Assessment for MS (BICAMS-A) and serum Brain-derived neurotrophic factor (BDNF).
Post-treatment, there was a significant increase of oral Symbol Digit Modalities Test (SDMT), California Verbal Learning Test II (CVLT-II), revised Brief Visuospatial retention Test (BVRT-R) of BICAMS-A and serum BDNF in both study and control groups. There was a significant increase in CVLT-II, BVRT-R of BICAMS-A and serum BDNF in the study group compared to the control group (P < 0.05).
Vestibular training is an effective and innovative approach for improving cognitive functions in PwMS.
PACTR202311670782148.
认知功能障碍在多发性硬化症患者（PwMS）中普遍存在，但治疗不足。即使在控制残疾状态的情况下，中枢前庭功能也与PwMS的多个认知领域相关。据我们所知，从未探讨过前庭训练对PwMS认知功能的有效性。本研究的目的是确定前庭训练对PwMS认知功能的影响。
40例复发缓解型多发性硬化症患者，主要表现为疲劳，被随机分为两组。对照组（GI）采用固定自行车训练进行有氧耐力训练。研究组（GII）除了进行与GI相同的有氧耐力训练外，还接受了设计好的前庭训练方案。使用阿拉伯语版的多发性硬化症简易国际认知评估量表（BICAMS-A）和血清脑源性神经营养因子（BDNF）在治疗前后评估认知结果指标。
治疗后，研究组和对照组的阿拉伯语版BICAMS-A的口语符号数字模式测验（SDMT）、加利福尼亚言语学习测验第二版（CVLT-II）、修订版简易视觉空间记忆测验（BVRT-R）以及血清BDNF均显著增加。与对照组相比，研究组的CVLT-II、BICAMS-A的BVRT-R和血清BDNF显著增加（P<0.05）。
前庭训练是改善PwMS认知功能的一种有效且创新的方法。
PACTR202311670782148。
