He Huan, Huang Weiwei, Pan Zigang, Wang Lingjun, Yang Zhongqi, Chen Zixin
State Key Laboratory of Traditional Chinese Medicine Syndrome, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China.
State Key Laboratory of Traditional Chinese Medicine Syndrome, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China; Guangzhou Key Laboratory of Chinese Medicine for Prevention and Treatment of Chronic Heart Failure, Guangzhou 510405, PR China.
Pharmacol Res. 2025 Jan;211:107555. doi: 10.1016/j.phrs.2024.107555. Epub 2024 Dec 20.
Heart failure (HF) remains one of the leading causes of high morbidity and mortality globally. Impaired cardiac energy metabolism plays a critical role in the pathological progression of HF. Various forms of HF exhibit marked differences in energy metabolism, particularly in mitochondrial function and substrate utilization. Recent studies have increasingly highlighted that improving energy metabolism in HF patients as a crucial treatment strategy. Mitochondrial transfer is emerging as a promising and precisely regulated therapeutic strategy for treating metabolic disorders. This paper specifically reviews the characteristics of mitochondrial energy metabolism across different types of HF and explores the modes and mechanisms of mitochondrial transfer between different cell types in the heart, such as cardiomyocytes, fibroblasts, and immune cells. We focused on the therapeutic potential of intercellular mitochondrial transfer in improving energy metabolism disorders in HF. We also discuss the role of signal transduction in mitochondrial transfer, highlighting that mitochondria not only function as energy factories but also play crucial roles in intercellular communication, metabolic regulation, and tissue repair. This study provides new insights into improving energy metabolism in heart failure patients and proposes promising new therapeutic strategies.
心力衰竭（HF）仍然是全球高发病率和高死亡率的主要原因之一。心脏能量代谢受损在HF的病理进展中起关键作用。各种形式的HF在能量代谢方面表现出显著差异，特别是在线粒体功能和底物利用方面。最近的研究越来越强调改善HF患者的能量代谢作为一种关键的治疗策略。线粒体转移正在成为一种有前景且精确调控的治疗代谢紊乱的策略。本文具体综述了不同类型HF中线粒体能量代谢的特征，并探讨了心脏中不同细胞类型（如心肌细胞、成纤维细胞和免疫细胞）之间线粒体转移的模式和机制。我们关注细胞间线粒体转移在改善HF能量代谢紊乱方面的治疗潜力。我们还讨论了信号转导在线粒体转移中的作用，强调线粒体不仅作为能量工厂发挥作用，而且在细胞间通讯、代谢调节和组织修复中也发挥关键作用。这项研究为改善心力衰竭患者的能量代谢提供了新的见解，并提出了有前景的新治疗策略。
