登革热感染会改变人类血小板中CD154和CD148的表达。
Dengue infection changes the expressions of CD154 and CD148 in human platelets.
作者信息
Vedpathak Sayali, Palkar Sonali, Mishra AkhileshChandra, Arankalle Vidya A, Shrivastava Shubham
机构信息
Department of Translational Virology, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Katraj-Dhankawadi, Pune 411043, India.
Department of Community Medicine, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Katraj-Dhankawadi, Pune 411043, India.
出版信息
Virus Res. 2025 Jan;351:199519. doi: 10.1016/j.virusres.2024.199519. Epub 2024 Dec 26.
Platelets are essential for hemostasis and vascular integrity. Platelets recognize dengue virus through the DC-SIGN receptor. Upon pathogen recognition, platelets rapidly modulate the expression of adhesion molecules to trigger immune cell interactions and regulate the immune response. In this study, we aimed to examine the expression levels of three molecules, CD151, CD154, and CD148 on platelets in dengue patients. A significantly increased expression of CD154 and reduced expression of CD148 was observed in dengue patients compared to healthy subjects (p < 0.0001). Moreover, a strong positive correlation between CD148 and CD41/CD61 (p < 0.0001) was noted in dengue patients. In summary, we demonstrated the altered expressions of CD154 and CD148 on platelets in dengue patients that may play a crucial role in dengue pathogenesis.
血小板对于止血和血管完整性至关重要。血小板通过DC-SIGN受体识别登革病毒。在识别病原体后，血小板迅速调节黏附分子的表达，以触发免疫细胞相互作用并调节免疫反应。在本研究中，我们旨在检测登革热患者血小板上三种分子CD151、CD154和CD148的表达水平。与健康受试者相比，登革热患者中观察到CD154表达显著增加，CD148表达降低（p < 0.0001）。此外，在登革热患者中，CD148与CD41/CD61之间存在强正相关（p < 0.0001）。总之，我们证明了登革热患者血小板上CD154和CD148的表达改变，这可能在登革热发病机制中起关键作用。
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