Ratain M J, Golomb H M, Vardiman J W, Vokes E E, Jacobs R H, Daly K
Blood. 1985 Mar;65(3):644-8.
Nine patients with progressive hairy cell leukemia were treated with subcutaneous injections of recombinant alpha 2 interferon (2 to 10 X 10(6) U/m2) three times weekly. Eight patients completed at least eight weeks of treatment and were evaluable; one patient with refractory thrombocytopenia died of an intracerebral hemorrhage after two doses of interferon. Seven of eight patients responded, with responses occurring as early as two weeks. Four patients also had resolution of their monocytopenia. No complete responses were seen with up to 30 weeks of treatment. Bone marrow biopsies demonstrated improvement in all eight patients. No unforeseen toxicity occurred, but most patients had transient myelosuppression during the first few weeks of treatment. Recombinant alpha 2 interferon is effective in the treatment of hairy cell leukemia, with acceptable toxicity.
9例进行性毛细胞白血病患者接受皮下注射重组α2干扰素治疗（2至10×10⁶U/m²），每周3次。8例患者完成了至少8周的治疗且可进行评估；1例难治性血小板减少症患者在注射两剂干扰素后死于脑出血。8例患者中有7例有反应，最早在两周时出现反应。4例患者的单核细胞减少症也得到缓解。治疗长达30周未见完全缓解。骨髓活检显示所有8例患者均有改善。未发生意外毒性，但大多数患者在治疗的最初几周有短暂的骨髓抑制。重组α2干扰素治疗毛细胞白血病有效，毒性可接受。
