Hryshchyshyn Andrii, Bahrii Andrii, Khimich Sergii, Bohush Hryhorii, Botsun Pavlina, Chuba Volodymyr
Medical Center Hormony, Vinnytsia, Ukraine.
National Pirogov Memorial Medical University, Vinnytsia, Ukraine.
J Med Case Rep. 2024 Dec 23;18(1):606. doi: 10.1186/s13256-024-04979-1.
In this article, we report a case of renal cell carcinoma metastasis to the thyroid gland. Occult lesions of the thyroid were treated with a thyroidectomy. The case history presented below describes the patient's pathway and subsequent results.
A routine medical examination of a 58-year-old Ukrainian woman revealed lesions in her thyroid gland. In total, two nodules 3.5 cm and 1.5 cm wide were found in the gland using ultrasound. Features of thyroid nodules were classified as Thyroid Imaging Reporting and Data System 3. A fine-needle aspiration biopsy showed Bethesda category IV thyroid nodules. Before this, the patient had a right-sided nephrectomy. The histopathology report confirmed renal cell carcinoma. The patient underwent a total thyroidectomy 13 years ago with confirmed metastatic renal cell carcinoma to the thyroid gland. Subsequent surgeries aimed at removing the local recurrences and distant metastases of the primary site. The patient got six cycles of Sunitinib (Sutent™, Pfizer) chemotherapy for renal cell carcinoma. Today, she lives in another country as a refugee and visits home occasionally. The patient takes thyroxine and waits for a suitable treatment option to cure advanced renal cell carcinoma.
A comprehensive investigation of the patient's case history is crucial for determining a correct diagnosis. In our case, metastases to the thyroid were found 13 years after the initial renal cell carcinoma diagnosis. Moreover, foci of renal cancer cells in other organs indicates advanced disease with subsequent recurrence and distant metastases. Renal cell carcinoma may cause thyroid nodules.
在本文中，我们报告了一例肾细胞癌转移至甲状腺的病例。对甲状腺隐匿性病变进行了甲状腺切除术治疗。以下呈现的病例病史描述了患者的诊疗过程及后续结果。
一名58岁乌克兰女性的常规体检发现其甲状腺有病变。通过超声检查，在甲状腺中总共发现了两个结节，分别为3.5厘米和1.5厘米宽。甲状腺结节的特征被归类为甲状腺影像报告和数据系统3类。细针穿刺活检显示为贝塞斯达IV类甲状腺结节。在此之前，该患者进行了右侧肾切除术。组织病理学报告证实为肾细胞癌。该患者于13年前接受了全甲状腺切除术，确诊为肾细胞癌转移至甲状腺。后续手术旨在切除原发部位的局部复发灶和远处转移灶。该患者接受了六个周期的舒尼替尼（索坦™，辉瑞公司）治疗肾细胞癌。如今，她作为难民生活在另一个国家，偶尔回家探亲。患者服用甲状腺素，等待合适的治疗方案来治愈晚期肾细胞癌。
对患者病例病史进行全面调查对于确定正确诊断至关重要。在我们的病例中，肾细胞癌初次诊断13年后发现了甲状腺转移。此外，其他器官中的肾癌细胞灶表明疾病已进展至伴有后续复发和远处转移。肾细胞癌可能导致甲状腺结节。
