耐药结核病对罗马尼亚布加勒斯特患者社会经济状况、生活质量及心理健康的影响：一项前瞻性队列研究

Impact of drug-resistant tuberculosis on socio-economic status, quality of life and psychological well-being of patients in Bucharest, Romania: a prospective cohort study.

作者信息

Ramachandran Rupa, Dumitrescu Andreea, Baiceanu Dragos, Popa Cristina, Dragomir Antonela, Mahler Beatrice, Hoelscher Michael, Lange Christoph, Heyckendorf Jan, Rachow Andrea, Ibraim Elmira, Ivanova Olena

机构信息

Deggendorf Institute of Technology, European Campus Rottal-Inn, 84347, Pfarrkirchen, Germany.

Marius Nasta Institute of Pneumology - German Centre for Infection Research (DZIF), Eastern European Study Site, Bucharest, Romania.

出版信息

J Health Popul Nutr. 2024 Dec 22;43(1):223. doi: 10.1186/s41043-024-00717-x.

DOI:10.1186/s41043-024-00717-x

PMID:39710755

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11665218/

Abstract

BACKGROUND

Tuberculosis (TB) remains a global health challenge, with 1.3 million deaths in 2022. Ten countries in the European Union (EU) and European Economic Area (EEA) accounted for 88.3% of TB cases, of which 23.8% were from Romania. Evidence shows that mental health issues, decreased quality of life and negative socio-economic impact are common among TB patients; however, there is limited evidence available in Romania. The main aim of this study is to longitudinally assess the quality of life, mental health, and socio-economic status of patients with drug-resistant TB (DR TB) in Romania.

METHODS

A prospective cohort study was conducted at the Marius Nasta Institute of Pneumology in Bucharest, Romania, enrolling 50 participants with DR TB. Demographic data, clinical examinations, laboratory test and medical history were recorded at study start. At baseline (week two), month 10, and month 20 we also administered the Short-Form-36 and Kessler Psychological Distress Scale to assess health-related quality of life and mental health status, and socio-economic questionnaires to 46 participants.

RESULTS

Of the 46 participants with median age of 48.9 years, 71.7% were males. Majority of the participants were employed at the baseline but due to the rigorous treatment and hospitalization had to take sick leave, thereby affecting the individual and household income. 26.1% and 39.3% of participants reported psychological distress at baseline and at the end of month 20, respectively. The quality-of-life scores improved during treatment: PCS with a mean of 67.0 (SD-33.9) at baseline, 63.3 (SD-31.9) at month 10 and 70.3 (SD-30.3) at month 20, and MCS with 62.8 (SD-30.6), 67.8 (SD-29) and 70.8 (SD-27.3), accordingly, but differences were not significant.

CONCLUSIONS

We examined the socio-economic impact, quality of life, and psychological distress among patients affected by DR TB in Romania. The results of this study suggest that social and psychological support will ensure a better standard of living during and following TB treatment.

摘要

背景

结核病仍然是一项全球性的健康挑战，2022年有130万人死亡。欧盟（EU）和欧洲经济区（EEA）的10个国家占结核病病例的88.3%，其中23.8%来自罗马尼亚。有证据表明，心理健康问题、生活质量下降和负面的社会经济影响在结核病患者中很常见；然而，罗马尼亚的相关证据有限。本研究的主要目的是纵向评估罗马尼亚耐多药结核病（DR-TB）患者的生活质量、心理健康和社会经济状况。

方法

在罗马尼亚布加勒斯特的马里乌斯·纳斯塔肺病研究所进行了一项前瞻性队列研究，招募了50名耐多药结核病患者。在研究开始时记录人口统计学数据、临床检查、实验室检查和病史。在基线（第2周）、第10个月和第20个月，我们还对46名参与者进行了简短健康调查问卷（Short-Form-36）和凯斯勒心理困扰量表测试，以评估健康相关生活质量和心理健康状况，并发放了社会经济调查问卷。

结果

46名参与者的中位年龄为48.9岁，其中71.7%为男性。大多数参与者在基线时都有工作，但由于严格的治疗和住院不得不请病假，从而影响了个人和家庭收入。分别有26.1%和39.3%的参与者在基线和第20个月末报告有心理困扰。治疗期间生活质量得分有所改善：身体功能（PCS）在基线时平均为67.0（标准差-33.9），第10个月为63.3（标准差-31.9），第20个月为70.3（标准差-30.3）；精神健康（MCS）相应地为62.8（标准差-30.6）、67.8（标准差-29）和70.8（标准差-27.3），但差异不显著。