Magacho-Vieira Fabiano Nadson
Magacho Institute for Health Education, Fortaleza, Ceará, Brazil.
Department of Clinical, Aesthetic and Surgical Dermatology, Batista Memorial Hospital, Fortaleza, Ceará, Brazil.
J Cosmet Dermatol. 2025 Feb;24(2):e16751. doi: 10.1111/jocd.16751. Epub 2024 Dec 22.
A recent study highlighted variability in complication rates among polylactic acid (PLA)-based collagen stimulator fillers, with notably high rate of complications linked to PLLA-Elleva. The study suggested that product-specific characteristics might have greater impact on outcomes than injection techniques.
METHODS/RESULTS: Through a critical analysis of pertinent literature, this commentary explores how PLLA-Elleva's unique physicochemical properties, particularly its bimodal degradation process, may contribute to the increased nodule formation observed.
Although PLLA-Elleva's degradation pattern does not inherently compromise safety, it introduces variability that requires careful attention to dosage, injection technique, and patient selection.
最近一项研究强调了基于聚乳酸（PLA）的胶原蛋白刺激填充剂并发症发生率的变异性，与聚左旋乳酸-艾丽薇（PLLA-Elleva）相关的并发症发生率尤其高。该研究表明，产品特定特性可能比注射技术对治疗结果有更大影响。
方法/结果：通过对相关文献的批判性分析，本评论探讨了PLLA-Elleva独特的物理化学性质，特别是其双峰降解过程，可能如何导致观察到的结节形成增加。
虽然PLLA-Elleva的降解模式本身并不影响安全性，但它引入了变异性，需要仔细关注剂量、注射技术和患者选择。
