Department of Pharmaceutical Sciences, University of Navarra, Irunlarrea 1, Pamplona E-31008, Spain.
Department of Pharmacology, Penn State College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, United States.
J Med Chem. 2024 May 23;67(10):7759-7787. doi: 10.1021/acs.jmedchem.3c02426. Epub 2024 May 8.
There is an urgent need to develop safer and more effective modalities for the treatment of a wide range of pathologies due to the increasing rates of drug resistance, undesired side effects, poor clinical outcomes, etc. Throughout the years, selenium (Se) has attracted a great deal of attention due to its important role in human health. Besides, a growing body of work has unveiled that the inclusion of Se motifs into a great number of molecules is a promising strategy for obtaining novel therapeutic agents. In the current Perspective, we have gathered the most recent literature related to the incorporation of different Se moieties into the scaffolds of a wide range of known drugs and their feasible pharmaceutical applications. In addition, we highlight different representative examples as well as provide our perspective on Se drugs and the possible future directions, promises, opportunities, and challenges of this ground-breaking area of research.
由于耐药性不断增加、不良反应不可取、临床效果不佳等原因，迫切需要开发更安全、更有效的治疗方法来治疗广泛的疾病。多年来，由于硒 (Se) 在人类健康中的重要作用，它引起了极大的关注。此外，越来越多的工作揭示了将 Se 基序纳入大量分子中是获得新型治疗剂的一种很有前途的策略。在本观点中，我们收集了与将不同 Se 部分纳入广泛已知药物结构及其可行药物应用相关的最新文献。此外，我们还强调了不同的代表性例子，并提供了我们对 Se 药物的看法以及该开创性研究领域的未来方向、前景、机遇和挑战。
