Rodríguez-Martín María, Salmerón Diego, Dashti Hassan S, Isabel Cascales Ana, Aragón-Alonso Aurora, Scheer Frank A J L, Saxena Richa, Garaulet Marta
Department of Physiology, University of Murcia, Murcia, Spain.
Biomedical Research Institute of Murcia, IMIB Arrixaca, University of Murcia, University Clinical Hospital, Murcia, Spain.
Obesity (Silver Spring). 2025 Jan;33(1):164-176. doi: 10.1002/oby.24173.
In this cross-sectional study, we aim to investigate the interactions between obesity, siesta behavior, and the genetic propensity for siesta in a Mediterranean population, in whom siesta is deeply rooted.
We applied a previously generated Siesta-Polygenic Score (PGS) in the ONTIME study (n = 1278). Siesta and other Mediterranean lifestyle behaviors were characterized using questionnaires. We further determined obesity grade. Secondarily, we measured weight loss during treatment as well as long-term weight-loss maintenance. Logistic regression analyses were performed to address our aim.
A total of 42.4% of the population usually took siesta. A significant genetic influence on siesta propensity was found, with a higher genetic predisposition linked to taking siesta more frequently (odds ratio [OR] = 1.17, 95% CI: 1.03-1.32; p = 0.015). Participants with a higher genetic propensity for siesta showed poorer dietary habits (p < 0.05). Among individuals with a high genetic propensity for siesta, we found that those who usually take siesta have lower odds of having obesity (p = 0.038) compared with those who do not. Similarly, in exploratory analysis, among individuals with a high genetic propensity for siesta, we found that those who usually take siesta have higher odds of weight-loss success (p = 0.007) compared with those who do not. CONCLUSIONS: Considering the ongoing debate regarding whether siesta is beneficial or detrimental, our findings suggest that individual genetic predisposition to siesta might influence the association between siesta and health.
在这项横断面研究中，我们旨在调查肥胖、午睡行为以及午睡遗传倾向在地中海人群中的相互作用，在地中海人群中，午睡是根深蒂固的。
我们在ONTIME研究（n = 1278）中应用了先前生成的午睡多基因评分（PGS）。午睡和其他地中海式生活方式行为通过问卷进行描述。我们进一步确定了肥胖等级。其次，我们测量了治疗期间的体重减轻以及长期的体重维持情况。进行逻辑回归分析以实现我们的目标。
共有42.4%的人群通常午睡。发现午睡倾向存在显著的遗传影响，遗传易感性越高与午睡频率越高相关（优势比[OR]=1.17，95%置信区间：1.03 - 1.32；p = 0.015）。午睡遗传倾向较高的参与者饮食习惯较差（p < 0.05）。在午睡遗传倾向较高的个体中，我们发现通常午睡的个体与不午睡的个体相比，肥胖几率更低（p = 0.038）。同样，在探索性分析中，在午睡遗传倾向较高的个体中，我们发现通常午睡的个体与不午睡的个体相比，减肥成功的几率更高（p = 0.007）。
考虑到关于午睡有益还是有害的持续争论，我们的研究结果表明，个体午睡的遗传易感性可能会影响午睡与健康之间的关联。
