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空肠回肠旁路术的13年回顾。

A 13-year review of jejunoileal bypass.

作者信息

McFarland R J, Gazet J C, Pilkington T R

出版信息

Br J Surg. 1985 Feb;72(2):81-7. doi: 10.1002/bjs.1800720202.

Abstract

One hundred and eighty patients had a jejunoileal bypass performed during the years 1971-1982. By leaving only 14 in. (35 cm) of intestine in continuity a mean weight loss of 34.4 per cent (s.d. = 8.5) was achieved over 2 years and, unless the operation had to be reversed for complications, this weight loss was maintained. The improvement in quality of life for a majority of patients should not be undervalued. Two-thirds of patients required admission for complications and eight patients died (4 per cent). Many of these problems were provoked by an inability to control eating. There have been no hospital deaths since 1976 which we attribute to better management of complications and a policy of early reversal for patients with excessive weight loss and signs of metabolic failure. Despite performing jejunoileal bypass less often in recent years we are still frequently reversing patients with electrolyte disturbances, metabolic failure, urinary calculi or arthritis. Thirty patients (16.7 per cent) have been reversed, half more than 5 years after bypass. Metabolic failure may occur even after many years of stable weight reduction. Because this is not well known the insidious onset of new weight loss and malaise may not be recognized, or not associated with the bypass many years before. Indefinite outpatient surveillance is mandatory. Changes in the operation have not significantly affected results. There has been no serious liver dysfunction in the 7:7:CJ group but this may reflect better management of lesser metabolic disturbances. Jejunoileal bypass remains the most effective operation for gross obesity and, with experience, can be performed safely. However, the complication rate and difficulty maintaining satisfactory follow-up on large numbers of young patients makes it an unacceptable procedure on any major scale.

摘要

1971年至1982年间,180例患者接受了空肠回肠分流术。通过仅保留14英寸(35厘米)连续的肠管,在两年内平均体重减轻了34.4%(标准差=8.5),并且除非因并发症而不得不进行手术逆转,否则这种体重减轻会持续保持。大多数患者生活质量的改善不容小觑。三分之二的患者因并发症需要住院治疗,8例患者死亡(4%)。许多这些问题是由无法控制饮食引发的。自1976年以来没有医院死亡病例,我们将其归因于对并发症的更好管理以及对体重过度减轻和代谢衰竭迹象患者采取的早期逆转政策。尽管近年来空肠回肠分流术的实施频率降低,但我们仍经常对患有电解质紊乱、代谢衰竭、尿路结石或关节炎的患者进行逆转手术。30例患者(16.7%)已被逆转,其中一半是在分流术后5年以上。即使经过多年体重稳定减轻,代谢衰竭仍可能发生。由于这一点并不广为人知,新的体重减轻和不适的隐匿发作可能未被认识到,或者在多年前未与分流术联系起来。必须进行不定期的门诊监测。手术方式的改变并未显著影响结果。7:7:CJ组未出现严重肝功能障碍,但这可能反映了对较轻代谢紊乱的更好管理。空肠回肠分流术仍然是治疗重度肥胖最有效的手术方法,并且凭借经验可以安全实施。然而,并发症发生率以及对大量年轻患者进行令人满意的随访的困难使得该手术在任何大规模应用中都不可接受。

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