Han Xu, Chen Jia, Cheng Zhihao, Zhou Shengwang
School of Pharmacy, Jiangsu University, Zhenjiang 212013, P. R. China.
Chem Commun (Camb). 2025 Jan 16;61(7):1407-1410. doi: 10.1039/d4cc05933f.
An anti-PD-L1 mediated nanodrug delivery system is developed by modifying the MOF surface and using Tpy-Gd-Tpy coordination chemistry, enabling the simultaneous delivery of chemotherapy and immunotherapy drugs. The platform enables regulated drug release and integrates multiple imaging modalities, promoting targeted delivery and facilitating tumor diagnosis through FL and MR imaging.
通过修饰金属有机框架（MOF）表面并利用三联吡啶-钆-三联吡啶配位化学，开发了一种抗程序性死亡配体1（PD-L1）介导的纳米药物递送系统，可同时递送化疗药物和免疫治疗药物。该平台能够实现药物的可控释放，并整合多种成像方式，通过荧光（FL）成像和磁共振（MR）成像促进靶向递送并助力肿瘤诊断。
