Wu Zichen, Xu Ke, Huang Regina, Wang Xinna, Teng Jade Lee-Lee, Yu Xiaolin, Jin Lijian, Li Quanli, Leung Ken Cham-Fai, Wong Hai Ming, Li Xuan
Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, PR China.
Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, PR China.
Mater Today Bio. 2025 Mar 7;31:101642. doi: 10.1016/j.mtbio.2025.101642. eCollection 2025 Apr.
The integration of living microbes, specifically bacteria and fungi, with metal-organic nanocoatings has led to the recent development of cyborg microbe biohybrids, which show excellent adaptability and functionality for a wide range of potential applications in biotechnology and medicine. This review discusses the strategies, functionalisation, and applications of these biohybrids, which are categorised into two types of coatings: metal-organic frameworks (MOFs) and metal-phenolic networks (MPNs). Key advances in their synthetic approaches and pre-synthesised coatings are crucially addressed, and yet the methodology details and specific advantages are highlighted. Despite the notable advancements, there are various limitations and challenges, such as determination of the long-term viability and stability of the biohybrids, insufficient work on their theranostic applications and essentially scaling-up difficulties for industrial and clinical translation. The latest advancements in the biohybrids and related technology have established a critical foundation for enhancing innovative studies through the strong interdisciplinary teamwork.
将活微生物，特别是细菌和真菌与金属有机纳米涂层相结合，催生了半机械人微生物生物杂交体的最新发展，这类生物杂交体在生物技术和医学的广泛潜在应用中展现出优异的适应性和功能性。本综述讨论了这些生物杂交体的策略、功能化及应用，它们被分为两种类型的涂层：金属有机框架（MOF）和金属酚醛网络（MPN）。重点阐述了其合成方法和预合成涂层方面的关键进展，同时突出了方法细节和具体优势。尽管取得了显著进展，但仍存在各种限制和挑战，如生物杂交体长期活力和稳定性的测定、其治疗诊断应用方面的研究不足以及工业和临床转化中本质上的扩大规模困难。生物杂交体及相关技术的最新进展通过强大的跨学科团队合作，为加强创新性研究奠定了关键基础。
