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迈向大流行防范:从纵向调查中估计高分辨率社会接触模式的能力。

Towards pandemic preparedness: ability to estimate high-resolution social contact patterns from longitudinal surveys.

作者信息

Dan Shozen, Tegegne Joshua, Chen Yu, Ling Zhi, Jaeger Veronika K, Karch André, Mishra Swapnil, Ratmann Oliver

机构信息

Imperial College London, Department of Mathematics, United Kingdom.

National University of Singapore, Saw Swee Hock School of Public Health, Singapore.

出版信息

Res Sq. 2024 Dec 11:rs.3.rs-5182601. doi: 10.21203/rs.3.rs-5182601/v1.

DOI:10.21203/rs.3.rs-5182601/v1
PMID:39711531
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11661306/
Abstract

Social contact surveys are an important tool to assess infection risks within populations, and the effect of non-pharmaceutical interventions on social behaviour during disease outbreaks, epidemics, and pandemics. Numerous longitudinal social contact surveys were conducted during the COVID-19 era, however data analysis is plagued by reporting fatigue, a phenomenon whereby the average number of social contacts reported declines with the number of repeat participations and as participants' engagement decreases over time. Using data from the German COVIMOD Study between April 2020 to December 2021, we demonstrate that reporting fatigue varied considerably by sociodemographic factors and was consistently strongest among parents reporting children contacts (parental proxy reporting), students, middle-aged individuals, those in full-time employment and those self-employed. We find further that, when using data from first-time participants as gold standard, statistical models incorporating a simple logistic function to control for reporting fatigue were associated with substantially improved estimation accuracy relative to models with no reporting fatigue adjustments, and that no cap on the number of repeat participations was required. These results indicate that existing longitudinal contact survey data can be meaningfully interpreted under an easy-to-implement statistical approach adressing reporting fatigue confounding, and that longitudinal designs including repeat participants are a viable option for future social contact survey designs.

摘要

社交接触调查是评估人群感染风险以及在疾病爆发、流行和大流行期间非药物干预对社会行为影响的重要工具。在新冠疫情期间进行了大量纵向社交接触调查,然而数据分析受到报告疲劳的困扰,报告疲劳是指随着重复参与次数的增加以及参与者参与度随时间下降,报告的社交接触平均数量会减少的一种现象。利用2020年4月至2021年12月德国COVIMOD研究的数据,我们证明报告疲劳在社会人口学因素方面差异很大,在报告与孩子接触的父母(父母代理报告)、学生、中年个体、全职工作者和自雇人士中始终最为明显。我们进一步发现,当将首次参与者的数据作为金标准时,相对于未进行报告疲劳调整的模型,纳入简单逻辑函数以控制报告疲劳的统计模型在估计准确性方面有显著提高,并且不需要对重复参与次数设限。这些结果表明,现有的纵向接触调查数据可以通过一种易于实施的统计方法来有效解释,该方法可解决报告疲劳带来的混淆问题,并且包括重复参与者的纵向设计对于未来的社交接触调查设计是一个可行的选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/281b/11661306/eae3a2f67fb1/nihpp-rs5182601v1-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/281b/11661306/bb8e58f42760/nihpp-rs5182601v1-f0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/281b/11661306/88916ce0d5e5/nihpp-rs5182601v1-f0003.jpg
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本文引用的文献

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Contact behaviour before, during and after the COVID-19 pandemic in the Netherlands: evidence from contact surveys, 2016 to 2017 and 2020 to 2023.新冠疫情前后荷兰的接触行为:来自 2016 年至 2017 年和 2020 年至 2023 年接触调查的证据。
Euro Surveill. 2024 Oct;29(43). doi: 10.2807/1560-7917.ES.2024.29.43.2400143.
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Longitudinal population-level HIV epidemiologic and genomic surveillance highlights growing gender disparity of HIV transmission in Uganda.纵向人群 HIV 流行病学和基因组监测突出了乌干达 HIV 传播中性别差距日益扩大的问题。
Nat Microbiol. 2024 Jan;9(1):35-54. doi: 10.1038/s41564-023-01530-8. Epub 2023 Dec 5.
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Examining the Influence of Imbalanced Social Contact Matrices in Epidemic Models.
考察不均衡社会接触矩阵在流行病模型中的影响。
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Estimating age-stratified transmission and reproduction numbers during the early exponential phase of an epidemic: A case study with COVID-19 data.估算传染病早期指数增长阶段的年龄分层传播数和繁殖数:以 COVID-19 数据为例的研究。
Epidemics. 2023 Sep;44:100714. doi: 10.1016/j.epidem.2023.100714. Epub 2023 Aug 15.
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Longitudinal social contact data analysis: insights from 2 years of data collection in Belgium during the COVID-19 pandemic.纵向社会接触数据分析:COVID-19 大流行期间在比利时进行 2 年数据收集的见解。
BMC Public Health. 2023 Jul 6;23(1):1298. doi: 10.1186/s12889-023-16193-7.
6
Estimating fine age structure and time trends in human contact patterns from coarse contact data: The Bayesian rate consistency model.从粗粒度接触数据估计人类接触模式的精细年龄结构和时间趋势:贝叶斯率一致性模型。
PLoS Comput Biol. 2023 Jun 5;19(6):e1011191. doi: 10.1371/journal.pcbi.1011191. eCollection 2023 Jun.
7
Social contact patterns during the COVID-19 pandemic in 21 European countries - evidence from a two-year study.21 个欧洲国家在 COVID-19 大流行期间的社会接触模式 - 来自为期两年的研究证据。
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8
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