Giesler G J, Cliffer K D
Brain Res. 1985 Feb 11;326(2):347-56. doi: 10.1016/0006-8993(85)90044-7.
The response characteristics of neurons at the origin of the postsynaptic dorsal column (PSDC) pathway were determined in unanesthetized, decerebrated, spinalized rats. Sixty-four percent of PSDC neurons responded only to innocuous mechanical stimuli. Thirty-six percent responded to innocuous stimuli but were more powerfully activated by noxious pinch. Ninety-three percent of the tested PSDC neurons were not activated by any of several intensities of sustained, repeated noxious heating of their receptive fields. The failure of pinch-responsive PSDC cells to respond to thermal stimulation, even in sensitized skin, suggests that they do not receive a functionally significant input from C polymodal nociceptors, heat nociceptors, or mechanical-heat nociceptors. We conclude, therefore, that the postsynaptic dorsal column pathway is not importantly involved in nociception in the rat.
在未麻醉、去大脑、脊髓横断的大鼠中，确定了突触后背柱（PSDC）通路起始处神经元的反应特性。64%的PSDC神经元仅对无害机械刺激有反应。36%的神经元对无害刺激有反应，但被有害捏压更强烈地激活。在所测试的PSDC神经元中，93%在其感受野受到几种强度的持续、重复有害热刺激时均未被激活。即使在致敏皮肤中，对捏压有反应的PSDC细胞对热刺激无反应，这表明它们没有从C类多模式伤害感受器、热伤害感受器或机械-热伤害感受器接收功能上重要的输入。因此，我们得出结论，突触后背柱通路在大鼠伤害感受中并不重要。
