Yan Yijiao, Deng Wenhui, Shi Chengzhi, Xie Jiaxin, Sui Daoshun
The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, China.
First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
Front Med (Lausanne). 2024 Dec 6;11:1500670. doi: 10.3389/fmed.2024.1500670. eCollection 2024.
Psoriasis is a chronic skin condition characterized by immune-mediated inflammation. Recent research suggests a possible interaction between infection and the immunopathogenesis of psoriasis. However, over the past 5 years, no significant new evidence has clarified the relationship between and skin diseases. This study aimed to determine the relationship between infection and psoriasis through a systematic review and meta-analysis.
We searched for articles published in databases including PubMed, Embase, the China National Knowledge Infrastructure, and Web of Science up to January 1, 2024. Statistical analyses were conducted using Review Manager 5.3 and Stata 12.0 software.
Our search yielded 271 papers. After rigorous screening by multiple reviewers, 15 studies involving 2,427 individuals were included. The odds ratio for infection was significantly higher in the psoriasis group than in the control group (odds ratio = 1.94, 95% confidence interval: 1.40-2.68, < 0.0001). Subgroup analysis revealed no significant differences in infection rates between Asia and Europe. The type of study also did not significantly affect infection rates. The enzyme-linked immunosorbent assay detected infection at a significantly higher rate than the breath test. Furthermore, the prevalence of infection differed significantly between patients with moderate-to-severe psoriasis and those with mild psoriasis.
Our findings suggest a relationship between psoriasis and infection, with variations observed based on geography, testing methods, and disease severity. These findings hold significant potential for guiding clinical practice.
http://www.crd.york.ac.uk/, identifier CRD42022359427.
银屑病是一种以免疫介导的炎症为特征的慢性皮肤病。最近的研究表明感染与银屑病的免疫发病机制之间可能存在相互作用。然而，在过去5年中，没有重要的新证据阐明[此处原文缺失感染相关具体病原体名称]与皮肤病之间的关系。本研究旨在通过系统评价和荟萃分析确定[此处原文缺失感染相关具体病原体名称]感染与银屑病之间的关系。
我们检索了截至2024年1月1日在包括PubMed、Embase、中国知网和科学网在内的数据库中发表的文章。使用Review Manager 5.3和Stata 12.0软件进行统计分析。
我们的检索产生了271篇论文。经过多位评审员的严格筛选，纳入了15项涉及2427名个体的研究。银屑病组[此处原文缺失感染相关具体病原体名称]感染的比值比显著高于对照组（比值比 = 1.94，95%置信区间：1.40 - 2.68，P < 0.0001）。亚组分析显示亚洲和欧洲之间[此处原文缺失感染相关具体病原体名称]感染率无显著差异。研究类型也未显著影响感染率。酶联免疫吸附测定法检测[此处原文缺失感染相关具体病原体名称]感染的速率显著高于呼气试验。此外，中度至重度银屑病患者与轻度银屑病患者之间[此处原文缺失感染相关具体病原体名称]感染的患病率存在显著差异。
我们的研究结果表明银屑病与[此处原文缺失感染相关具体病原体名称]感染之间存在关联，根据地理区域、检测方法和疾病严重程度观察到了差异。这些发现对指导临床实践具有重要潜力。
