Alpdemir Medine, Alpdemir Mehmet Fatih, Şeneş Mehmet
University of Health Sciences, Ankara Training and Research Hospital, Medical Biochemistry, Ankara, Türkiye.
University of Health Sciences, Ankara Bilkent City Hospital, Medical Biochemistry, Ankara, Türkiye.
J Med Biochem. 2024 Sep 6;43(5):671-680. doi: 10.5937/jomb0-46549.
The study was a retrospective investigation by the Department of Medical Biochemistry of the Ankara Training and Research Hospital between January 1, 2021, and December 31, 2022. Our study evaluated the results of 6297 patients aged 18-95 years who underwent cholesterol panel TC, TG, HDL-C, and direct LDL-C in our laboratory. The estimated LDL-C was calculated according to Friedewald, Martin/Hopkins, and Sampson formulae.
All three formulae showed a stronger positive correlation with d-LDL-C (0.905, 0.897, and 0.886, respectively, for all data, p<0.001). In addition, when we compared the total median difference (1st-3rd quartile) of all formulae, it was -0.69 (-1.62 to 0.39) for Friedewald, 0.034 (-0.74 to 1.14) for Martin/Hopkins and -0.40 (-1.19 to 0.55) for Sampson. According to Passing Bablok regression analyses, the intercept was determined as -0.97 (95% CI=-1.01 to -0.93), 0.41 (95%=0.37 to 0.44) and -0.05 (-0.08 to -0. 03) and slopes were calculated as 1.083 (95% CI=1.07-1.09), 0.88 (0.88 to 0.89) and 0. 90 (95%=0.89 to 0.90) for Friedewald, Martin/Hopkins and Sampson, respectively.
Our findings suggest that the Martin/Hopkins formula performed better than the Friedewald and Sampson formulas. We figured out utilizing the Martin/ Hopkins formula as a good alternative for estimated LDLC in Turkish adults.
本研究是安卡拉培训与研究医院医学生物化学科在2021年1月1日至2022年12月31日期间进行的一项回顾性调查。我们的研究评估了在我们实验室接受胆固醇检测项目（总胆固醇、甘油三酯、高密度脂蛋白胆固醇和直接低密度脂蛋白胆固醇）检测的6297例年龄在18至95岁患者的检测结果。估计的低密度脂蛋白胆固醇根据弗里德瓦尔德公式、马丁/霍普金斯公式和桑普森公式计算得出。
所有三个公式与直接低密度脂蛋白胆固醇均呈现更强的正相关性（所有数据分别为0.905、0.897和0.886，p<0.001）。此外，当我们比较所有公式的总中位数差异（第一四分位数至第三四分位数）时，弗里德瓦尔德公式为-0.69（-1.62至0.39），马丁/霍普金斯公式为0.034（-0.74至1.14），桑普森公式为-0.40（-1.19至0.55）。根据帕辛·巴布洛克回归分析，弗里德瓦尔德公式、马丁/霍普金斯公式和桑普森公式的截距分别确定为-0.97（95%置信区间=-1.01至-0.93）、0.41（95%=0.37至0.44）和-0.05（-0.08至-0.03），斜率分别计算为1.083（95%置信区间=1.07至1.09）、0.88（0.88至0.89）和0.90（95%=0.89至0.90）。
我们的研究结果表明，马丁/霍普金斯公式的表现优于弗里德瓦尔德公式和桑普森公式。我们发现，在土耳其成年人中，使用马丁/霍普金斯公式作为估计低密度脂蛋白胆固醇的良好替代方法。
