Fathi Mobina, Taher Hayder Jasim, Al-Rubiae Sabah Jassim, Yaghoobpoor Shirin, Bahrami Ashkan, Eshraghi Reza, Sadri Hossein, Asadi Anar Mahsa, Gholamrezanezhad Ali
Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1983969411, Iran.
Department of Radiology, Hilla University College, Babylon 00964, Iraq.
World J Methodol. 2024 Dec 20;14(4):93461. doi: 10.5662/wjm.v14.i4.93461.
One of the leading causes of cancer-related death is gastrointestinal cancer, which has a significant morbidity and mortality rate. Although preoperative risk assessment is essential for directing patient care, its biological behavior cannot be accurately predicted by conventional imaging investigations. Potential pathophysiological information in anatomical imaging that cannot be visually identified can now be converted into high-dimensional quantitative image features thanks to the developing discipline of molecular imaging. In order to enable molecular tissue profile , molecular imaging has most recently been utilized to phenotype the expression of single receptors and targets of biological therapy. It is expected that molecular imaging will become increasingly important in the near future, driven by the expanding range of biological therapies for cancer. With this live molecular fingerprinting, molecular imaging can be utilized to drive expression-tailored customized therapy. The technical aspects of molecular imaging are first briefly discussed in this review, followed by an examination of the most recent research on the diagnosis, prognosis, and potential future clinical methods of molecular imaging for GI tract malignancies.
胃肠道癌是癌症相关死亡的主要原因之一，其发病率和死亡率都很高。尽管术前风险评估对指导患者护理至关重要，但传统的影像学检查无法准确预测其生物学行为。由于分子成像学科的发展，解剖成像中无法通过视觉识别的潜在病理生理信息现在可以转化为高维定量图像特征。为了实现分子组织剖析，分子成像最近已被用于对生物治疗的单一受体和靶点的表达进行表型分析。预计在癌症生物治疗范围不断扩大的推动下，分子成像在不久的将来将变得越来越重要。通过这种实时分子指纹识别，分子成像可用于推动针对表达的定制治疗。本文首先简要讨论分子成像的技术方面，然后考察分子成像在胃肠道恶性肿瘤诊断、预后及未来潜在临床应用方面的最新研究。
