Mao Yuhang, Xie Juanping, Yang Fang, Luo Yan, Du Juan, Xiang Hong
School of Medicine, Ankang University, Ankang, China.
Ultrasound Medicine Department, Ankang Traditional Chinese Medicine Hospital, Ankang, China.
Front Cell Dev Biol. 2024 Dec 5;12:1514399. doi: 10.3389/fcell.2024.1514399. eCollection 2024.
Tumor, as the second leading cause of death globally, following closely behind cardiovascular diseases, remains a significant health challenge worldwide. Despite the existence of various cancer treatment methods, their efficacy is still suboptimal, necessitating the development of safer and more efficient treatment strategies. Additionally, the advancement of personalized therapy offers further possibilities in cancer treatment. Nanomedicine, as a promising interdisciplinary field, has shown tremendous potential and prospects in the diagnosis and treatment of cancer. As an emerging approach in oncology, the application of nanomedicine in personalized cancer therapy primarily focuses on targeted drug delivery systems such as passive targeting drug delivery, active targeting drug delivery, and environmentally responsive targeting drug delivery, as well as imaging diagnostics such as tumor biomarker detection, tumor cell detection, and imaging. However, it still faces challenges regarding safety, biocompatibility, and other issues. This review aims to explore the advances in the use of nanomaterials in the field of personalized cancer diagnosis and treatment and to investigate the prospects and challenges of developing personalized therapies in cancer care, providing direction for the clinical translation and application.
肿瘤是全球第二大死因，紧随心血管疾病之后，仍然是全球重大的健康挑战。尽管存在各种癌症治疗方法，但其疗效仍不尽人意，因此需要开发更安全、更有效的治疗策略。此外，个性化治疗的进展为癌症治疗提供了更多可能性。纳米医学作为一个有前途的跨学科领域，在癌症的诊断和治疗中显示出巨大的潜力和前景。作为肿瘤学中的一种新兴方法，纳米医学在个性化癌症治疗中的应用主要集中在靶向给药系统，如被动靶向给药、主动靶向给药和环境响应靶向给药，以及成像诊断，如肿瘤生物标志物检测、肿瘤细胞检测和成像。然而，它在安全性、生物相容性和其他问题方面仍然面临挑战。本综述旨在探讨纳米材料在个性化癌症诊断和治疗领域的应用进展，并研究在癌症护理中开发个性化治疗的前景和挑战，为临床转化和应用提供方向。
