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生物制品、治疗诊断学和个性化医学在药物传递系统中的应用。

Biologics, theranostics, and personalized medicine in drug delivery systems.

机构信息

Department of Pharmaceutical Sciences, University of Perugia, Italy,.

Department of Medicine and Surgery, University, Italy.

出版信息

Pharmacol Res. 2024 Mar;201:107086. doi: 10.1016/j.phrs.2024.107086. Epub 2024 Jan 29.


DOI:10.1016/j.phrs.2024.107086
PMID:38295917
Abstract

The progress in human disease treatment can be greatly advanced through the implementation of nanomedicine. This approach involves targeted and cell-specific therapy, controlled drug release, personalized dosage forms, wearable drug delivery, and companion diagnostics. By integrating cutting-edge technologies with drug delivery systems, greater precision can be achieved at the tissue and cellular levels through the use of stimuli-responsive nanoparticles, and the development of electrochemical sensor systems. This precision targeting - by virtue of nanotechnology - allows for therapy to be directed specifically to affected tissues while greatly reducing side effects on healthy tissues. As such, nanomedicine has the potential to transform the treatment of conditions such as cancer, genetic diseases, and chronic illnesses by facilitating precise and cell-specific drug delivery. Additionally, personalized dosage forms and wearable devices offer the ability to tailor treatment to the unique needs of each patient, thereby increasing therapeutic effectiveness and compliance. Companion diagnostics further enable efficient monitoring of treatment response, enabling customized adjustments to the treatment plan. The question of whether all the potential therapeutic approaches outlined here are viable alternatives to current treatments is also discussed. In general, the application of nanotechnology in the field of biomedicine may provide a strong alternative to existing treatments for several reasons. In this review, we aim to present evidence that, although in early stages, fully merging advanced technology with innovative drug delivery shows promise for successful implementation across various disease areas, including cancer and genetic or chronic diseases.

摘要

通过实施纳米医学,可以极大地推动人类疾病治疗的进展。这种方法涉及靶向和细胞特异性治疗、控制药物释放、个性化剂型、可穿戴药物输送和伴随诊断。通过将尖端技术与药物输送系统集成,可以通过使用对刺激响应的纳米粒子和开发电化学传感器系统,在组织和细胞水平上实现更高的精度。这种通过纳米技术实现的精确靶向,使得治疗可以专门针对受影响的组织,同时大大减少对健康组织的副作用。因此,纳米医学有可能通过促进精确和细胞特异性的药物输送,改变癌症、遗传疾病和慢性疾病等疾病的治疗方式。此外,个性化剂型和可穿戴设备能够根据每个患者的独特需求定制治疗,从而提高治疗效果和顺应性。伴随诊断进一步能够有效地监测治疗反应,从而能够对治疗计划进行定制调整。这里概述的所有潜在治疗方法是否都是当前治疗方法的可行替代方案,这也是一个需要讨论的问题。总的来说,纳米技术在生物医学领域的应用可能为现有治疗方法提供一个强有力的替代方案,原因有几个。在这篇综述中,我们旨在提供证据表明,尽管处于早期阶段,但将先进技术与创新药物输送完全融合,有望在包括癌症、遗传或慢性疾病在内的各个疾病领域成功实施。

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