• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一例嗜酸细胞性肾上腺皮质癌的组织形态学和超微结构报告及临床放射学相关性

A Histomorphologic and Ultrastructural Report of an Oncocytic Adrenal Cortical Carcinoma With Clinicoradiologic Correlates.

作者信息

Santos Christine D, Carbonell Dennis Jose S

机构信息

Department of Pathology and Laboratory Medicine, National Kidney and Transplant Institute, Quezon City, PHL.

出版信息

Cureus. 2024 Nov 21;16(11):e74184. doi: 10.7759/cureus.74184. eCollection 2024 Nov.

DOI:10.7759/cureus.74184
PMID:39712708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11663143/
Abstract

Oncocytic adrenal cortical carcinoma (ACC) is a rare malignant adrenal cortical tumor with limited documented case reports. Herein, a 65-year-old female patient presented with a large, solid adrenal mass. A diagnosis of oncocytic ACC was rendered with the following tumor characteristics: The tumor entirely consists of diffuse sheets of polygonal cells with bizarre nuclear atypia and deeply eosinophilic cytoplasm. The panel of immunohistochemistry revealed its adrenocortical nature, with synaptophysin and melan-A expression and the corresponding negativity of pancytokeratin and chromogranin. Moreover, an ultrastructural demonstration of the oncocytic nature of the mass is also presented.

摘要

嗜酸性肾上腺皮质癌（ACC）是一种罕见的肾上腺皮质恶性肿瘤，文献记载的病例报告有限。在此，一名65岁女性患者出现一个巨大的实性肾上腺肿块。根据以下肿瘤特征诊断为嗜酸性ACC：肿瘤完全由弥漫性的多边形细胞片组成，细胞核异型性明显且细胞质呈深嗜酸性。免疫组织化学检测显示其肾上腺皮质性质，突触素和黑色素A呈阳性表达，而全细胞角蛋白和嗜铬粒蛋白呈阴性。此外，还展示了该肿块嗜酸性性质的超微结构证明。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a28/11663143/f2cd3db79579/cureus-0016-00000074184-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a28/11663143/abea847fd1e0/cureus-0016-00000074184-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a28/11663143/48803784e948/cureus-0016-00000074184-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a28/11663143/9c008f5b5e34/cureus-0016-00000074184-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a28/11663143/4e59b4e893d1/cureus-0016-00000074184-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a28/11663143/f2cd3db79579/cureus-0016-00000074184-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a28/11663143/abea847fd1e0/cureus-0016-00000074184-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a28/11663143/48803784e948/cureus-0016-00000074184-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a28/11663143/9c008f5b5e34/cureus-0016-00000074184-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a28/11663143/4e59b4e893d1/cureus-0016-00000074184-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a28/11663143/f2cd3db79579/cureus-0016-00000074184-i05.jpg

相似文献

1
A Histomorphologic and Ultrastructural Report of an Oncocytic Adrenal Cortical Carcinoma With Clinicoradiologic Correlates.一例嗜酸细胞性肾上腺皮质癌的组织形态学和超微结构报告及临床放射学相关性
Cureus. 2024 Nov 21;16(11):e74184. doi: 10.7759/cureus.74184. eCollection 2024 Nov.
2
Symptomatic intraspinal oncocytic adrenocortical adenoma.有症状的脊髓内嗜酸性肾上腺皮质腺瘤
Endocr Pathol. 2009 Spring;20(1):73-7. doi: 10.1007/s12022-008-9051-1.
3
A rare case of oncocytic adrenocortical carcinoma clinically presented as an incidentaloma.临床上偶发瘤形式表现出的嗜酸细胞瘤性肾上腺皮质癌罕见病例。
Endocr J. 2020 Aug 28;67(8):883-888. doi: 10.1507/endocrj.EJ20-0024. Epub 2020 May 4.
4
Adrenocortical oncocytic neoplasm: A systematic review.促肾上腺皮质腺瘤性嗜酸细胞瘤：系统评价。
Surgery. 2018 Dec;164(6):1351-1359. doi: 10.1016/j.surg.2018.04.044. Epub 2018 Jul 21.
5
A Case of Oncocytic Adrenal Cortical Neoplasm with Uncertain Malignant Potential Turned Out to Be Oncocytic Adrenal Cortical Carcinoma with Distant Metastasis: Could Pathology Do Better Initially?一例具有不确定恶性潜能的嗜酸细胞瘤样肾上腺皮质肿瘤最终被诊断为具有远处转移的嗜酸细胞瘤样肾上腺皮质癌：最初病理科能否做得更好？
Medicina (Kaunas). 2022 Jul 6;58(7):900. doi: 10.3390/medicina58070900.
6
Oncocytic adrenocortical carcinoma: a rare adrenal tumor subtype.嗜酸细胞性肾上腺皮质癌：一种罕见的肾上腺肿瘤亚型。
Can J Urol. 2017 Jun;24(3):8865-8867.
7
A Case of Oncocytic Adrenocortical Neoplasm of Borderline (Uncertain) Malignant Potential.一例具有边缘性（不确定）恶性潜能的嗜酸性肾上腺皮质肿瘤
Cureus. 2016 Jun 13;8(6):e638. doi: 10.7759/cureus.638.
8
Limitation of the current Lin-Weiss-Bisceglia criteria in predicting poor prognosis in oncocytic adrenocortical neoplasms of uncertain malignant potential and oncocytoma diagnosed by the Lin-Weiss-Bisceglia criteria.当前林-魏斯-比塞利亚标准在预测具有不确定恶性潜能的嗜酸细胞性肾上腺皮质肿瘤以及根据林-魏斯-比塞利亚标准诊断的嗜酸细胞瘤预后不良方面的局限性。
Ther Adv Endocrinol Metab. 2025 Apr 30;16:20420188251328186. doi: 10.1177/20420188251328186. eCollection 2025.
9
[Adrenocortical Oncocytic Tumor : A Report of Two Cases].[肾上腺皮质嗜酸细胞瘤：2例报告]
Hinyokika Kiyo. 2022 Feb;68(2):41-45. doi: 10.14989/ActaUrolJap_68_2_41.
10
Oncocytic adrenocortical carcinoma.嗜酸细胞瘤性肾上腺皮质癌。
Ann Diagn Pathol. 2010 Jun;14(3):204-8. doi: 10.1016/j.anndiagpath.2009.06.006. Epub 2009 Sep 8.

引用本文的文献

1
Non-functional oncocytic adrenocortical carcinoma: Case report with clinicopathologic and surgical correlation.无功能性嗜酸性肾上腺皮质癌：病例报告及临床病理与手术相关性分析
Urol Case Rep. 2025 Aug 20;62:103171. doi: 10.1016/j.eucr.2025.103171. eCollection 2025 Sep.

本文引用的文献

1
European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.欧洲内分泌学会与欧洲肾上腺肿瘤研究网络合作制定的关于肾上腺意外瘤处理的临床实践指南。
Eur J Endocrinol. 2023 Jul 20;189(1):G1-G42. doi: 10.1093/ejendo/lvad066.
2
Adrenocortical Carcinoma: Updates of Clinical and Pathological Features after Renewed World Health Organisation Classification and Pathology Staging.肾上腺皮质癌：世界卫生组织重新分类及病理分期后临床与病理特征的更新
Biomedicines. 2021 Feb 10;9(2):175. doi: 10.3390/biomedicines9020175.
3
Data set for reporting of carcinoma of the adrenal cortex: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting.
国际癌症报告协作组织关于肾上腺皮质癌报告的数据集：解释和建议。
Hum Pathol. 2021 Apr;110:50-61. doi: 10.1016/j.humpath.2020.10.001. Epub 2020 Oct 12.
4
A rare case of oncocytic adrenocortical carcinoma clinically presented as an incidentaloma.临床上偶发瘤形式表现出的嗜酸细胞瘤性肾上腺皮质癌罕见病例。
Endocr J. 2020 Aug 28;67(8):883-888. doi: 10.1507/endocrj.EJ20-0024. Epub 2020 May 4.
5
Oncocytic adrenocortical neoplasms--a clinicopathologic study of 13 new cases emphasizing the importance of their recognition.嗜酸细胞瘤性肾上腺皮质肿瘤——13 例新病例的临床病理研究，强调其识别的重要性。
Hum Pathol. 2011 Apr;42(4):489-99. doi: 10.1016/j.humpath.2010.08.010. Epub 2011 Jan 14.
6
Adjuvant mitotane treatment for adrenocortical carcinoma.米托坦辅助治疗肾上腺皮质癌。
N Engl J Med. 2007 Jun 7;356(23):2372-80. doi: 10.1056/NEJMoa063360.
7
Adrenocortical oncocytic tumors: report of 10 cases and review of the literature.肾上腺皮质嗜酸性细胞瘤：10例报告并文献复习
Int J Surg Pathol. 2004 Jul;12(3):231-43. doi: 10.1177/106689690401200304.
8
Oncocytic adrenocortical carcinoma: a morphologic, immunohistochemical and ultrastructural study of four cases.嗜酸性肾上腺皮质癌：4例病例的形态学、免疫组织化学及超微结构研究
Mod Pathol. 2002 Sep;15(9):973-8. doi: 10.1038/modpathol.3880638.
9
Oncocytic adrenal cortical carcinoma.嗜酸细胞性肾上腺皮质癌
Ultrastruct Pathol. 1991 Jul-Oct;15(4-5):549-56. doi: 10.3109/01913129109016262.