Murugesan Induparkavi, Kailashiya Vikas, Data Sahil, Bhardwaj Madan Gopal, Trivedi Sameer
Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Department of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Urol Case Rep. 2025 Aug 20;62:103171. doi: 10.1016/j.eucr.2025.103171. eCollection 2025 Sep.
Oncocytic adrenocortical carcinoma (OACC) is a rare variant of adrenocortical carcinoma composed predominantly of oncocytic cells. We present the case of a 45-year-old female with a large, non-functional left adrenal mass diagnosed as OACC. Imaging revealed a well-defined, vascular, heterogeneously enhancing mass without metastasis. Histopathology showed oncocytic cells disposed in nests and sheets with capsular and venous invasion, with low mitotic activity. Surgical excision was curative, and the patient remains disease-free at 10 months. This case highlights the diagnostic and prognostic utility of histologic scoring systems and underlines the role of surgery as the primary treatment in localized OACC.
嗜酸性肾上腺皮质癌（OACC）是肾上腺皮质癌的一种罕见变体，主要由嗜酸性细胞组成。我们报告一例45岁女性，其左肾上腺有一个巨大的无功能肿块，诊断为OACC。影像学检查显示肿块边界清晰、有血管、强化不均匀且无转移。组织病理学显示嗜酸性细胞呈巢状和片状排列，有包膜和静脉侵犯，有丝分裂活性低。手术切除可治愈，患者在10个月时仍无疾病。该病例突出了组织学评分系统的诊断和预后价值，并强调了手术作为局限性OACC主要治疗方法的作用。
