Hobbs Landon, Bardhi Redina, Shah Priyanka, Rajabi-Estarabadi Ali, Akhtar Asfa
Department of Dermatology, Cleveland Clinic Florida, Weston, USA.
Cureus. 2024 Nov 20;16(11):e74087. doi: 10.7759/cureus.74087. eCollection 2024 Nov.
Syphilis is a sexually acquired disease that can affect multiple organ systems. Secondary syphilis can cause a wide range of skin manifestations, leading to misdiagnoses. Herein, we present a patient who developed a diffuse maculopapular rash concerning for a drug reaction leading to a dermatology consult. The patient was found to have secondary syphilis confirmed with immunohistochemical staining on skin biopsy tissue and a positive rapid plasma reagin. Appropriate management with benzathine penicillin G led to significant improvement in the rash. Given the increasing incidence of syphilis, increased awareness of the disease is imperative so that it can be considered in all patients given the highly variable presentation and likely confusion, at least initially, with drug reaction with eosinophilia and systemic symptoms syndrome and other drug eruptions.
梅毒是一种通过性传播的疾病，可影响多个器官系统。二期梅毒可导致多种皮肤表现，从而导致误诊。在此，我们报告一名患者，该患者出现了弥漫性斑丘疹皮疹，疑似药物反应，因此咨询了皮肤科。经皮肤活检组织免疫组化染色及快速血浆反应素阳性证实该患者患有二期梅毒。使用苄星青霉素G进行适当治疗后，皮疹有显著改善。鉴于梅毒发病率不断上升，必须提高对该疾病的认识，以便在所有患者中考虑到该病，因为其表现高度可变，至少在最初可能会与伴有嗜酸性粒细胞增多和全身症状综合征的药物反应及其他药疹相混淆。
