Du Dongru, Luo Jianjun, Cai Weiling, Qin Jiangyue, Yang Yao, Hu Xueru, Li Xiaohua, Luo Fengming, Shen Yongchun
Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610064, People's Republic of China.
State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, 610064, People's Republic of China.
Nat Sci Sleep. 2024 Dec 18;16:2099-2110. doi: 10.2147/NSS.S491657. eCollection 2024.
To investigate whether self-reported symptoms of obstructive sleep apnea (OSA), including snoring, snorting/stopping breathing, and sleepiness, are associated with increased risk of kidney stones.
This cross-sectional study was conducted based on the 2015-2020 National Health and Nutrition Examination Survey (NHANES). Self-reported symptoms of OSA and history of kidney stones were diagnosed via questionnaires. Multivariable logistic regression was used to determine the associations between self-reported symptoms of OSA and kidney stones. Subgroup analyses and interaction tests were performed to address this issue further.
A total of 9,973 participants were enrolled, and the prevalence of kidney stones was 10.76%. Although no significant association was observed between frequent snoring and kidney stones after covariate adjustments (OR 1.033, 95% CI 0.726, 1.469 p = 0.850), frequent snorting/stopping breathing was associated with a greater risk of kidney stones after covariate adjustments (OR 1.655, 95% CI 1.262, 2.172, p = 0.002). Participants who often or almost always felt sleepy also had a greater risk of kidney stones after covariate adjustment (OR 1.651, 95% CI 1.222, 2.229; p = 0.004). The interaction tests suggested that marital status (p = 0.015) and smoking status (p < 0.001) significantly interacted with the association between snorting/stopping breathing and kidney stones.
Self-reported frequent snorting/stopping breathing and sleepiness may be associated with increased risk of kidney stones. Although these findings may emphasize prevention of kidney stones in these people, further research was still needed to verify our results.
探讨自我报告的阻塞性睡眠呼吸暂停（OSA）症状，包括打鼾、鼻鼾/呼吸暂停和嗜睡，是否与肾结石风险增加有关。
本横断面研究基于2015 - 2020年国家健康与营养检查调查（NHANES）进行。通过问卷诊断自我报告的OSA症状和肾结石病史。采用多变量逻辑回归确定自我报告的OSA症状与肾结石之间的关联。进行亚组分析和交互作用检验以进一步解决该问题。
共纳入9973名参与者，肾结石患病率为10.76%。尽管在调整协变量后，频繁打鼾与肾结石之间未观察到显著关联（比值比1.033，95%置信区间0.726，1.469；p = 0.850），但在调整协变量后，频繁鼻鼾/呼吸暂停与肾结石风险增加有关（比值比1.655，95%置信区间1.262，2.172；p = 0.002）。经常或几乎总是感到困倦的参与者在调整协变量后患肾结石的风险也更高（比值比1.651，95%置信区间1.222，2.229；p = 0.004）。交互作用检验表明，婚姻状况（p = 0.015）和吸烟状况（p < 0.001）与鼻鼾/呼吸暂停和肾结石之间的关联存在显著交互作用。
自我报告的频繁鼻鼾/呼吸暂停和嗜睡可能与肾结石风险增加有关。尽管这些发现可能强调对这些人群进行肾结石预防，但仍需要进一步研究来验证我们的结果。
