Liu Ying, Wang Li, Bao Er-Hao, Wang Jia-Hao, Yang Lin, Wang Lei, Xia Long, Wang Ben, Zhu Ping-Yu
Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People's Republic of China.
Department of Urology, The Second Hospital of Lanzhou University, Lanzhou, People's Republic of China.
Nat Sci Sleep. 2024 Oct 3;16:1557-1568. doi: 10.2147/NSS.S483343. eCollection 2024.
The prevalence of Obstructive Sleep Apnea (OSA) is high, and there are many complications. Few studies have reported the relationship between OSA and kidney stones. The purpose of this study is to explore whether people at risk of OSA will increase the risk of kidney stones.
This was a cross-sectional study, and information was collected through the National Health and Nutrition Examination Survey conducted from 2015 to 2018. Multiple logistic regression analyses were employed to calculate the odds ratios (ORs) and their 95% confidence intervals (CIs) for the link between obstructive sleep apnea and the presence of kidney stones. Additionally, to assess causality and reduce observational biases, five distinct two-sample Mendelian randomization techniques were applied.
Following the adjustment for relevant confounders, findings indicated a statistically significant correlation between obstructive sleep apnea (OSA) and higher prevalence of kidney stones (OR = 1.29; 95% CI: 1.00-1.66). Additionally, using the inverse-variance weighted approach in Mendelian randomization, results suggested a genetic predisposition to OSA might be causally linked to an elevated risk of developing kidney stones (OR: 1.00221, 95% CI 1.00056-1.00387).
OSA promotes the formation of kidney stones, and the treatment and management of OSA can improve or mitigate the occurrence of kidney stones.
阻塞性睡眠呼吸暂停（OSA）的患病率很高，且存在许多并发症。很少有研究报道OSA与肾结石之间的关系。本研究的目的是探讨有OSA风险的人群是否会增加患肾结石的风险。
这是一项横断面研究，通过2015年至2018年进行的国家健康和营养检查调查收集信息。采用多元逻辑回归分析来计算阻塞性睡眠呼吸暂停与肾结石存在之间联系的比值比（OR）及其95%置信区间（CI）。此外，为了评估因果关系并减少观察性偏倚，应用了五种不同的两样本孟德尔随机化技术。
在对相关混杂因素进行调整后，研究结果表明阻塞性睡眠呼吸暂停（OSA）与较高的肾结石患病率之间存在统计学上的显著相关性（OR = 1.29；95% CI：1.00 - 1.66）。此外，在孟德尔随机化中使用逆方差加权方法，结果表明OSA的遗传易感性可能与患肾结石风险的升高存在因果关系（OR：1.00221，95% CI 1.00056 - 1.00387）。
OSA促进肾结石的形成，对OSA的治疗和管理可以改善或减轻肾结石的发生。
