Boddie A W, Merritt D R, Yamanashi W, Frazer J W, McBride C M, Martin R G
Cancer. 1985 Mar 15;55(6):1172-7. doi: 10.1002/1097-0142(19850315)55:6<1172::aid-cncr2820550605>3.0.co;2-e.
A hybrid radiofrequency heating system previously reported to produce highly focused heating patterns at less than or equal to 10 cm depth in phantom models was utilized to selectively heat hypervascular, heat resistant rabbit V-2 tumors implanted in the left hindlimb. Spheroidal heating patterns 3 to 4 cm in diameter with minimal temperatures of 43 degrees C to 46 degrees C in two non-field perturbing probes at opposing edges of the tumor were consistently produced; however, temperature maxima 0.5 +/- 0.4 to 8.6 +/- 5.9 degrees C above minimum target temperatures of 43 degrees C and 46 degrees C, respectively, were observed. This led to both tumor regressions and adjacent normal tissue damage in some animals. These findings suggest this system may have application to selective heating of deep seated tumors, but that problems related to accurate thermal mapping and to intratumor temperature distribution must first be resolved.
一种先前报道的能在体模模型中在小于或等于10厘米深度处产生高度聚焦加热模式的混合射频加热系统，被用于选择性加热植入左后肢的高血管、耐热兔V-2肿瘤。在肿瘤相对边缘的两个非场干扰探针中，持续产生直径为3至4厘米的球形加热模式，最低温度为43摄氏度至46摄氏度；然而，分别观察到温度最大值比43摄氏度和46摄氏度的最低目标温度高出0.5±0.4至8.6±5.9摄氏度。这导致一些动物出现肿瘤消退和相邻正常组织损伤。这些发现表明该系统可能适用于深部肿瘤的选择性加热，但与精确热成像和肿瘤内温度分布相关的问题必须首先得到解决。
