Boddie A W, Wright K, Frazer J W, Stephens L C, McBride C M, Wallace S, Martin R G
Invest Radiol. 1985 Oct;20(7):736-41. doi: 10.1097/00004424-198510000-00014.
Utilizing technology recently developed in our laboratory, hypervascular, heat-resistant V-2 tumors growing in the rabbit hindlimb were variously subjected to selective vascular occlusion by embolization with Dextran M microspheres and focal hyperthermia to minimum intratumor temperatures of 43 degrees C X 40 minutes (OH), focal 43 degrees C X 40 minutes hyperthermia alone (H), selective occlusion plus sham hyperthermia (O), and sham treatment. Regional toxicity observed consisted of skin burns and muscle fibrosis in the H and OH groups and peripheral embolization in the O alone group. Tumors subjected to a single OH treatment had significantly reduced growth rate over a 28-day period of observation compared with all other treatment groups and sham-treated controls (P less than or equal to .05). Our findings suggest that the combination of selective vascular embolization and focused hyperthermia may be useful in therapy of hypervascular, heat-resistant human tumors in anatomic locations where selective occlusion and relatively intense focal heating can be performed. The regional toxicity encountered in this model reemphasizes the need for extensive thermal mapping over the heated region.
利用我们实验室最近开发的技术，对生长在兔后肢的高血管性、耐热性V-2肿瘤进行了不同处理，通过用右旋糖酐M微球栓塞进行选择性血管闭塞，并进行局部热疗，使肿瘤内最低温度达到43摄氏度并持续40分钟（OH组），单独进行43摄氏度×40分钟的局部热疗（H组），选择性闭塞加假热疗（O组），以及假治疗。观察到的局部毒性包括H组和OH组的皮肤烧伤和肌肉纤维化，以及仅O组的外周栓塞。与所有其他治疗组和假治疗对照组相比，接受单次OH治疗的肿瘤在28天的观察期内生长速率显著降低（P小于或等于0.05）。我们的研究结果表明，选择性血管栓塞和聚焦热疗的联合应用可能对解剖位置上的高血管性、耐热性人类肿瘤治疗有用，在这些位置可以进行选择性闭塞和相对强烈的局部加热。该模型中遇到的局部毒性再次强调了在加热区域进行广泛热图绘制的必要性。
