Elwyn K E, Jones R D, Romsdahl M M
Cancer. 1985 Mar 15;55(6):1186-9. doi: 10.1002/1097-0142(19850315)55:6<1186::aid-cncr2820550608>3.0.co;2-t.
A study was done to determine if continuous administration of exogenous secretin would inhibit the trophic effect of elevated endogenous gastrin on colon neoplasms in rats. Colon tumors were induced in 37 Fisher rats by subcutaneous injection of 1,2-symdimethylhydrazine, 20 mg/kg, weekly for 18 weeks. Elevation of endogenous gastrin was achieved by antral exclusion surgery. Control rats received a sham operation. Subcutaneous osmotic minipumps delivered 35.5 U/kg/day of secretin for 7 days before the rats were killed. Rats receiving antral exclusion had significantly elevated serum gastrin levels and increased 3H-thymidine incorporation into tumor DNA compared with sham rats (P less than 0.05). There was a significant decrease in tumor DNA uptake in antral exclusion rats that received secretin as compared with antral exclusion rats without secretin (P less than 0.05). Therefore it appears that gastrin does have a trophic effect on rat colon neoplasms and that secretin does inhibit this effect, in a dose-related manner. The results of this study imply that hormonal manipulation of colon cancer may eventually become a viable therapeutic modality.
进行了一项研究，以确定持续给予外源性促胰液素是否会抑制内源性胃泌素升高对大鼠结肠肿瘤的营养作用。通过每周皮下注射1,2-二甲基肼（20 mg/kg），持续18周，在37只Fisher大鼠中诱发结肠肿瘤。通过胃窦切除术使内源性胃泌素升高。对照大鼠接受假手术。在大鼠处死前7天，皮下渗透微型泵每天输送35.5 U/kg的促胰液素。与假手术大鼠相比，接受胃窦切除术的大鼠血清胃泌素水平显著升高，肿瘤DNA中3H-胸腺嘧啶核苷掺入增加（P<0.05）。与未接受促胰液素的胃窦切除术大鼠相比，接受促胰液素的胃窦切除术大鼠的肿瘤DNA摄取显著降低（P<0.05）。因此，胃泌素似乎确实对大鼠结肠肿瘤有营养作用，促胰液素确实以剂量相关的方式抑制这种作用。这项研究的结果表明，结肠癌的激素调控最终可能成为一种可行的治疗方式。
