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用于肿瘤细胞中pH/谷胱甘肽/近红外三重响应药物释放及协同治疗的磁性纳米载体

Magnetic Nanocarriers for pH/GSH/NIR Triple-Responsive Drug Release and Synergistic Therapy in Tumor Cells.

作者信息

Zhang Di, Wei Wanyu, Xie Tianxiang, Zhou Xue, He Xu, Qiao Jie, Guo Rui, Jin Gang, Li Ningbo

机构信息

School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China.

School of Stomatology, Shanxi Medical University, Taiyuan 030001, China.

出版信息

ACS Omega. 2024 Dec 4;9(50):49749-49758. doi: 10.1021/acsomega.4c08267. eCollection 2024 Dec 17.

DOI:10.1021/acsomega.4c08267
PMID:39713612
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11656227/
Abstract

In this study, the mesoporous FeO nanodrug carriers containing disulfide bonds (CHO-SMNPs) were successfully synthesized and characterized. Doxorubicin (DOX) was loaded onto the CHO-SMNPs as a model drug and gatekeeper through the formation of imine bonds with the aldehyde groups on the surface of the mesoporous materials. This drug carrier demonstrates effective drug release triggered by pH, glutathione (GSH), and near-infrared (NIR) light, along with satisfactory photothermal conversion efficiency under NIR irradiation at 808 nm. Furthermore, CHO-SMNPs exhibit excellent blood compatibility and biodegradability. They also show good biocompatibility and efficient cellular uptake in HeLa and MCF-7 cancer cells. Most importantly, the CHO-SMNPs/DOX has shown significant effectiveness in killing both HeLa and MCF-7 cancer cells. Consequently, CHO-SMNPs/DOX presents substantial potential as a magnetic-targeted, pH/GSH/NIR triple-triggered drug delivery system for synergistic chemo-photothermal therapy in tumor treatment.

摘要

在本研究中，成功合成并表征了含二硫键的介孔FeO纳米药物载体（CHO-SMNPs）。阿霉素（DOX）作为模型药物和门控剂，通过与介孔材料表面的醛基形成亚胺键负载到CHO-SMNPs上。这种药物载体表现出由pH、谷胱甘肽（GSH）和近红外（NIR）光触发的有效药物释放，以及在808nm近红外照射下令人满意的光热转换效率。此外，CHO-SMNPs表现出优异的血液相容性和生物降解性。它们在HeLa和MCF-7癌细胞中也显示出良好的生物相容性和高效的细胞摄取。最重要的是，CHO-SMNPs/DOX在杀死HeLa和MCF-7癌细胞方面已显示出显著效果。因此，CHO-SMNPs/DOX作为一种用于肿瘤治疗中协同化疗-光热疗法的磁靶向、pH/GSH/NIR三重触发药物递送系统具有巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/fdbe07a80203/ao4c08267_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/9b4259d9a2f7/ao4c08267_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/3883d534b687/ao4c08267_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/da86d31989b0/ao4c08267_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/a7f8a5541881/ao4c08267_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/d50affe8a93c/ao4c08267_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/ebcb8615c50d/ao4c08267_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/d0585150d315/ao4c08267_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/abb5db710bd4/ao4c08267_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/fdbe07a80203/ao4c08267_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/9b4259d9a2f7/ao4c08267_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/3883d534b687/ao4c08267_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/da86d31989b0/ao4c08267_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/a7f8a5541881/ao4c08267_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/d50affe8a93c/ao4c08267_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/ebcb8615c50d/ao4c08267_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/d0585150d315/ao4c08267_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/abb5db710bd4/ao4c08267_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d694/11656227/fdbe07a80203/ao4c08267_0008.jpg

相似文献

[1]
Magnetic Nanocarriers for pH/GSH/NIR Triple-Responsive Drug Release and Synergistic Therapy in Tumor Cells.

ACS Omega. 2024-12-4

[2]
Triple stimuli-responsive ZnO quantum dots-conjugated hollow mesoporous carbon nanoplatform for NIR-induced dual model antitumor therapy.

J Colloid Interface Sci. 2019-9-30

[3]
Multimodal Mesoporous Silica Nanocarriers for Dual Stimuli-Responsive Drug Release and Excellent Photothermal Ablation of Cancer Cells.

Int J Nanomedicine. 2020-10-8

[4]
Multi-stimuli responsive mesoporous silica-coated carbon nanoparticles for chemo-photothermal therapy of tumor.

Colloids Surf B Biointerfaces. 2020-6

[5]
Gold nanoparticle-gated mesoporous silica as redox-triggered drug delivery for chemo-photothermal synergistic therapy.

J Colloid Interface Sci. 2017-8-16

[6]
Tumor-targeted and multi-stimuli responsive drug delivery system for near-infrared light induced chemo-phototherapy and photoacoustic tomography.

Acta Biomater. 2016-4-16

[7]
Rational assembly of RGD/MoS/Doxorubicin nanodrug for targeted drug delivery, GSH-stimulus release and chemo-photothermal synergistic antitumor activity.

J Photochem Photobiol B. 2022-8

[8]
Near-infrared light triggered drug delivery system for higher efficacy of combined chemo-photothermal treatment.

Acta Biomater. 2017-3-15

[9]
SiO-coated magnetic nano-FeO photosensitizer for synergistic tumour-targeted chemo-photothermal therapy.

Colloids Surf B Biointerfaces. 2020-11

[10]
Thermo- and pH-dual responsive polymeric micelles with upper critical solution temperature behavior for photoacoustic imaging-guided synergistic chemo-photothermal therapy against subcutaneous and metastatic breast tumors.

Theranostics. 2018-7-16

本文引用的文献

[1]
Cargo-loaded lipid-shielded breakable organosilica nanocages for enhanced drug delivery.

Nanoscale. 2023-9-14

[2]
Lutein-loaded chitosan/alginate-coated FeO nanoparticles as effective targeted carriers for breast cancer treatment.

Int J Biol Macromol. 2023-7-1

[3]
Synthesis of Monodispersed Hollow Mesoporous Organosilica and Silica Nanoparticles with Controllable Shell Thickness Using Soft and Hard Templates.

Langmuir. 2023-4-4

[4]
Nanoparticle drug delivery systems for synergistic delivery of tumor therapy.

Front Pharmacol. 2023-2-16

[5]
Synthesis of chitosan succinate-g-amine functionalized mesoporous silica: Inorganic-organic nanohybrid for antibacterial assessment, antioxidant activity and pH-controlled drug delivery.

Int J Biol Macromol. 2023-4-15

[6]
Magnetic Targeting Nanocarriers Combined with Focusing Ultrasound for Enhanced Intracerebral Hemorrhage Therapy.

Small. 2023-4

[7]
Nanomaterial-based CT contrast agents and their applications in image-guided therapy.

Theranostics. 2023

[8]
Mesoporous Silica Nanoparticles-Based Nanoplatforms: Basic Construction, Current State, and Emerging Applications in Anticancer Therapeutics.

Adv Healthc Mater. 2023-6

[9]
Multifunctional Superparticles for Magnetically Targeted NIR-II Imaging and Photodynamic Therapy.

Adv Sci (Weinh). 2023-1

[10]
Multifunctional plasmonic-magnetic nanoparticles for bioimaging and hyperthermia.

Adv Drug Deliv Rev. 2022-10

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