Wei Yi, Yu Jiangyi
Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Front Nutr. 2024 Dec 6;11:1495792. doi: 10.3389/fnut.2024.1495792. eCollection 2024.
Cardiometabolic index (CMI) is a novel marker that can assess metabolic status. Studies have found that people with diabetes mellitus (DM) are at high risk of developing frailty. However, there is a lack of evidence between CMI and the risk of frailty in patients with DM. Therefore, the aim of this study was to investigate the association between CMI and frailty in patients with DM.
This study utilized data from the 2005-2018 National Health and Nutrition Examination Survey (NHANES). Weighted multivariate logistic regression was conducted in this study to explore the association between CMI and frailty status in patients with DM. In addition, subgroup analyses and interaction analyses were conducted to assess heterogeneity between different subgroups. Subsequently, restricted cubic spline (RCS) was also used to test for non-linear relationships.
This study ultimately included 2,761 patients with DM. Weighted multivariate logistic regression showed that, after adjusting all covariates, an increase in the level of CMI was associated with an increased risk of being in a frailty status in patients with DM (OR = 1.12, 95% CI = 1.04-1.22, = 0.005). Dividing CMI into tertiles, the risk of frailty in patients in the highest tertile (Q3) was higher than that of patients in Q1 (OR = 1.56, 95% CI = 1.18-2.07, = 0.002). The non-linear relationship between CMI and the risk of frailty in DM patients was further confirmed by RCS analysis.
This study found that the higher the CMI, the higher the risk of frailty in DM patients. Maintaining a healthy low-fat dietary pattern and properly controlling blood lipid levels may reduce the risk of frailty in patients with DM.
心脏代谢指数（CMI）是一种可评估代谢状态的新型标志物。研究发现，糖尿病（DM）患者发生衰弱的风险很高。然而，缺乏CMI与DM患者衰弱风险之间的证据。因此，本研究的目的是调查CMI与DM患者衰弱之间的关联。
本研究利用了2005 - 2018年国家健康与营养检查调查（NHANES）的数据。本研究进行了加权多因素逻辑回归，以探讨CMI与DM患者衰弱状态之间的关联。此外，进行了亚组分析和交互分析，以评估不同亚组之间的异质性。随后，还使用限制立方样条（RCS）来检验非线性关系。
本研究最终纳入了2761例DM患者。加权多因素逻辑回归显示，在调整所有协变量后，CMI水平升高与DM患者处于衰弱状态的风险增加相关（比值比[OR] = 1.12，95%置信区间[CI] = 1.04 - 1.22，P = 0.005）。将CMI分为三分位数，最高三分位数（Q3）患者的衰弱风险高于Q1患者（OR = 1.56，95% CI = 1.18 - 2.07，P = 0.002）。RCS分析进一步证实了CMI与DM患者衰弱风险之间的非线性关系。
本研究发现，DM患者的CMI越高，衰弱风险越高。保持健康的低脂饮食模式并适当控制血脂水平可能会降低DM患者的衰弱风险。
