Bian Xue-Ying, Shao Xiao-Li, Yu Dong, Yang Wen-Xian
Department of Pediatrics, Shaoxing People's Hospital, The First Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, 312000, P. R. China.
Department of Pediatrics, Yiwu Central Hospital, Yiwu, Zhejiang, 322000, P. R. China.
Mol Neurobiol. 2025 May;62(5):6102-6111. doi: 10.1007/s12035-024-04665-9. Epub 2024 Dec 23.
This report aimed to analyze the potential effects of cytokines and neutrophils-to-lymphocytes ratio (NLR) on the occurrence of febrile seizures (FS) in children during the epidemic of novel coronavirus and influenza virus. Between July 2022 and April 2023, clinical data of 422 children with FS hospitalized in the Pediatrics, Shaoxing People's Hospital and the First Affiliated Hospital of Shaoxing University, during the epidemic and non-epidemic periods of novel coronavirus and influenza virus were analyzed. By comparing the various clinical characteristics of children with FS at different periods, comparison of variations in peripheral blood cell count, neutrophils, lymphocytes, hypersensitive C-creation protein, NLR, and inflammatory cytokines. Among 422 cases, 130 cases were classified as complex FS (CFS), while 292 cases of simple FS (SFS) were identified. During the time of the viral epidemic, 315 FS cases were observed, among which the incidence of CFS was 33.65%. In the non-viral epidemic period, there were 105 cases of FS. The incidence of CFS accounted for 22.86%. In addition, the levels of IL-4, IL-10, and tumor necrosis factor α (TNF-α) in children in the viral epidemic period were significantly higher than those in the non-epidemic period (P < 0.05). ROC curve analysis revealed that during the epidemic period, NLR (AUC = 0.724), IL-4 (AUC = 0.826), and IL-10 (AUC = 0.688) exhibited high predictive value for CFS children, and the indexes were statistically significant (P < 0.05). This study suggests that IL-4, IL-10, and NLR may play an important role in the pathogenesis of children with FS, especially those with CFS.
本报告旨在分析细胞因子和中性粒细胞与淋巴细胞比值（NLR）对新型冠状病毒和流感病毒流行期间儿童热性惊厥（FS）发生的潜在影响。2022年7月至2023年4月，分析了绍兴市人民医院和绍兴文理学院附属医院儿科收治的422例FS患儿在新型冠状病毒和流感病毒流行期与非流行期的临床资料。通过比较不同时期FS患儿的各项临床特征，对比外周血细胞计数、中性粒细胞、淋巴细胞、超敏C反应蛋白、NLR及炎性细胞因子的变化情况。422例患儿中，130例被分类为复杂性FS（CFS），292例为简单性FS（SFS）。在病毒流行期间，观察到315例FS病例，其中CFS的发生率为33.65%。在非病毒流行期，有105例FS病例。CFS的发生率占22.86%。此外，病毒流行期患儿的白细胞介素-4（IL-4）、白细胞介素-10（IL-10）和肿瘤坏死因子α（TNF-α）水平显著高于非流行期（P＜0.05）。ROC曲线分析显示，在流行期间，NLR（曲线下面积[AUC]=0.724）、IL-4（AUC=0.826）和IL-10（AUC=0.688）对CFS患儿具有较高的预测价值，且这些指标具有统计学意义（P＜0.05）。本研究表明，IL-4、IL-10和NLR可能在FS患儿尤其是CFS患儿的发病机制中起重要作用。
