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Psychoactive Substances: Transforming the Paradigm for Treating Mental Health Disorders in the Post-Pandemic Era.

作者信息

Zhai Haojiang, Wang Yibo, Wang Xiaohui

机构信息

Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.

School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China.

出版信息

Neurosci Bull. 2025 Mar;41(3):536-538. doi: 10.1007/s12264-024-01341-9. Epub 2024 Dec 23.

DOI:10.1007/s12264-024-01341-9
PMID:39714569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11876472/
Abstract
摘要

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本文引用的文献

1
DNA methylation and the opposing NMDAR dysfunction in schizophrenia and major depression disorders: a converging model for the therapeutic effects of psychedelic compounds in the treatment of psychiatric illness.精神分裂症和重度抑郁症中的 DNA 甲基化和相反的 NMDA 功能障碍：致幻化合物治疗精神疾病的疗效的汇聚模型。
Mol Psychiatry. 2023 Nov;28(11):4553-4567. doi: 10.1038/s41380-023-02235-4. Epub 2023 Sep 7.
2
Is Target-Based Drug Discovery Efficient? Discovery and "Off-Target" Mechanisms of All Drugs.基于靶点的药物发现是否高效？所有药物的发现与“脱靶”机制。
J Med Chem. 2023 Sep 28;66(18):12651-12677. doi: 10.1021/acs.jmedchem.2c01737. Epub 2023 Sep 6.
3
Psilocybin for the treatment of anorexia nervosa.裸盖菇素用于治疗神经性厌食症。
Nat Med. 2023 Aug;29(8):1906-1907. doi: 10.1038/s41591-023-02458-6.
4
MDMA-Assisted Therapy for Severe PTSD: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study.摇头丸辅助治疗重度创伤后应激障碍：一项随机、双盲、安慰剂对照的3期研究。
Focus (Am Psychiatr Publ). 2023 Jul;21(3):315-328. doi: 10.1176/appi.focus.23021011. Epub 2023 Jun 28.
5
Psychedelics reopen the social reward learning critical period.迷幻剂重新开启社会奖励学习的关键期。
Nature. 2023 Jun;618(7966):790-798. doi: 10.1038/s41586-023-06204-3. Epub 2023 Jun 14.
6
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB.迷幻剂通过直接与脑源性神经营养因子受体 TrkB 结合来促进可塑性。
Nat Neurosci. 2023 Jun;26(6):1032-1041. doi: 10.1038/s41593-023-01316-5. Epub 2023 Jun 5.
7
SnapShot: Psychedelics and serotonin receptor signaling.简讯：迷幻剂与血清素受体信号传导
Cell. 2023 Jan 5;186(1):232-232.e1. doi: 10.1016/j.cell.2022.12.020.
8
Modulation of DNA methylation and protein expression in the prefrontal cortex by repeated administration of D-lysergic acid diethylamide (LSD): Impact on neurotropic, neurotrophic, and neuroplasticity signaling.反复给予 D-麦角酸二乙酰胺（LSD）对前额叶皮层 DNA 甲基化和蛋白质表达的调制：对神经营养、神经营养和神经可塑性信号的影响。
Prog Neuropsychopharmacol Biol Psychiatry. 2022 Dec 20;119:110594. doi: 10.1016/j.pnpbp.2022.110594. Epub 2022 Jun 28.
9
Mental health in people with covid-19.新冠肺炎患者的心理健康
BMJ. 2022 Feb 16;376:o415. doi: 10.1136/bmj.o415.
10
Molecular insights into psychedelic drug action.迷幻药作用的分子见解。
J Neurochem. 2022 Jul;162(1):24-38. doi: 10.1111/jnc.15540. Epub 2021 Dec 1.