Zhao Fengping, Lei Changrong, Zhang Yue, Wu Shuangqing, Lin Haishuang, Chen De-Fu, Lin Chuanqi, Xiong Kun, Dai Mali, Zhang Shaodan, Li Duo, Liang Yuanbo
Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.
National Clinical Research Center for Ocular Diseases, Wenzhou, China.
BMC Ophthalmol. 2024 Dec 23;24(1):545. doi: 10.1186/s12886-024-03814-x.
Recent studies have indicated that oxidative stress is a crucial pathophysiological process in glaucoma. We hypothesized that Posner-Schlossman syndrome (PSS) is a vascular inflammation in the ciliary body due to oxidative stress and endothelial dysfunction. Thus, we investigated serum uric acid (UA) and lipid levels in patients with refractory PSS with the aim of providing basic evidence for the mechanism of PSS.
This is a retrospective, case-control study. A total of 81 refractory PSS and 409 control participants were included in this study. Clinical and laboratory characteristics were reviewed using an electronic medical system. Propensity score-matched (PSM) analysis was performed to reduce demographic differences. The t-test, Mann-Whitney U test, and χ2 test were used to assess the differences between the PSS and control groups. Logistic regression analysis was used to identify the predictors of PSS.
The higher serum UA (364.14 ± 98.72µmol/L vs. 322.38 ± 72.09µmol/L), higher low-density lipoprotein (LDL) / High-density lipoprotein (HDL) ratio (2.50 ± 0.97 vs. 1.95 ± 0.72) and lower HDL (1.29 ± 0.32 mmol/L vs. 1.59 ± 0.38 mmol/L) can be noticed in refractory PSS than control group. Logistics regression identified UA > 420 µmol/L (OR = 4.461) and the HDL < 1.03 mmol/L (OR = 3.896) were the independent risk factors for refractory PSS.
Increasing serum UA and decreasing HDL levels were positively correlated with the incidence risk of refractory PSS. Further prospective longitudinal studies and animal models are needed.
近期研究表明，氧化应激是青光眼关键的病理生理过程。我们推测，波斯纳-施洛斯曼综合征（PSS）是由于氧化应激和内皮功能障碍导致的睫状体血管炎症。因此，我们调查了难治性PSS患者的血清尿酸（UA）和血脂水平，旨在为PSS的发病机制提供基础证据。
这是一项回顾性病例对照研究。本研究共纳入81例难治性PSS患者和409例对照参与者。使用电子医疗系统回顾临床和实验室特征。进行倾向得分匹配（PSM）分析以减少人口统计学差异。采用t检验、曼-惠特尼U检验和χ2检验评估PSS组与对照组之间的差异。采用逻辑回归分析确定PSS的预测因素。
与对照组相比，难治性PSS患者血清UA水平较高（364.14±98.72µmol/L对322.38±72.09µmol/L）低密度脂蛋白（LDL）/高密度脂蛋白（HDL）比值较高（2.50±0.97对1.95±0.72），HDL水平较低（1.29±0.32 mmol/L对1.59±0.38 mmol/L）。逻辑回归分析确定UA>420µmol/L（OR=4.461）和HDL<1.03 mmol/L（OR=3.896）是难治性PSS的独立危险因素。
血清UA升高和HDL水平降低与难治性PSS的发病风险呈正相关。需要进一步进行前瞻性纵向研究和动物模型研究。
