Zhang Jiaying, Zhao Sifang, Zhou Yifan, Liang Hongze, Zhao Lingling, Tan Hui
School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 311215, China.
Infectious Diseases Department, Shenzhen Children's Hospital, Shenzhen, 518038, China.
Adv Healthc Mater. 2025 Feb;14(4):e2403198. doi: 10.1002/adhm.202403198. Epub 2024 Dec 23.
Diabetic wound healing is hampered due to oxidative stress, exacerbated inflammation, and impaired angiogenesis in the wounds. A pH-sensitive antioxidant hydrogel based on carboxymethyl chitosan (CMCS), oligoprocyanidins (OPC), and oxide dextran (Oxd) is prepared to accelerate diabetic wound healing. The hydrogel network is formed via imine and hydrogen bonding interactions in the presence of hydroxyl, amino, and aldehyde groups, and deferoxamine (DFO) is incorporated into the hydrogel. The hydrogel shows pH-triggered drug release, a good antioxidant, and anti-inflammatory properties, and can promote tube formation and cell migration in vitro. Moreover, the hydrogel can accelerate wound healing in streptozotocin (STZ)-induced diabetic mice by regulating the inflammation environment with up-regulation of anti-inflammatory factors (IL-4 and IL-10) and down-regulation of pro-inflammatory factors (TNF-α and IL-6), and promoting angiogenesis with up-regulation of HIF-1α, VEGF, and CD31. Thus, the pH-sensitive antioxidant hydrogel provides a promising therapeutic strategy for diabetic wound healing.
糖尿病伤口愈合受到氧化应激、炎症加剧和伤口血管生成受损的阻碍。制备了一种基于羧甲基壳聚糖（CMCS）、低聚原花青素（OPC）和氧化葡聚糖（Oxd）的pH敏感抗氧化水凝胶，以加速糖尿病伤口愈合。水凝胶网络是在羟基、氨基和醛基存在的情况下通过亚胺和氢键相互作用形成的，并且将去铁胺（DFO）掺入水凝胶中。该水凝胶表现出pH触发的药物释放、良好的抗氧化和抗炎特性，并且在体外可以促进血管生成和细胞迁移。此外，该水凝胶可以通过上调抗炎因子（IL-4和IL-10）和下调促炎因子（TNF-α和IL-6）来调节炎症环境，并通过上调HIF-1α、VEGF和CD31来促进血管生成，从而加速链脲佐菌素（STZ）诱导的糖尿病小鼠的伤口愈合。因此，这种pH敏感抗氧化水凝胶为糖尿病伤口愈合提供了一种有前景的治疗策略。
