• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

高龄产妇中PD-1增强的调节性T细胞衰老

PD-1-Enhanced Treg Cell Senescence in Advanced Maternal Age.

作者信息

Gong Guang-Shun, Zhang Yu-Jing, Hu Xiao-Hui, Lin Xin-Xiu, Liao Ai-Hua

机构信息

Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P. R. China.

Department of Obstetrics and Gynecology, First Clinical College Union Hospital Huazhong University of Science and Technology, Wuhan, 430022, P. R. China.

出版信息

Adv Sci (Weinh). 2025 Feb;12(6):e2411613. doi: 10.1002/advs.202411613. Epub 2024 Dec 23.

DOI:10.1002/advs.202411613
PMID:39716882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11809324/
Abstract

Senescence occurs earlier in the immune system than in solid organs as age increases. Regulatory T (Treg) cells are among the first cells to exhibit signs of aging. However, whether advanced-age pregnancy involves Treg cell aging remains unclear. This study demonstrated that the aging of women is accompanied by aging Treg cells and that PD-1 regulates Treg cell aging. The transfer of young Treg cells can improve the pregnancy outcomes of reproductive-aged mice by reducing the level of IFN-γ, a proinflammatory cytokine secreted by Treg cells in aged mice. Transferring α-PD-1 mAb-treated aged Treg cells increases the level of IL-10, an anti-inflammatory cytokine secreted by Treg cells in reproductive-aged mice. Collectively, these findings suggest a potential therapeutic strategy for preventing adverse pregnancy outcomes in older women.

摘要

随着年龄增长，衰老在免疫系统中比在实体器官中更早出现。调节性T（Treg）细胞是最早出现衰老迹象的细胞之一。然而，高龄妊娠是否涉及Treg细胞衰老仍不清楚。本研究表明，女性衰老伴随着Treg细胞衰老，且程序性死亡受体1（PD-1）调节Treg细胞衰老。年轻Treg细胞的转移可通过降低老年小鼠中Treg细胞分泌的促炎细胞因子γ干扰素（IFN-γ）水平来改善育龄小鼠的妊娠结局。转移经α-PD-1单克隆抗体处理的老年Treg细胞可提高育龄小鼠中Treg细胞分泌的抗炎细胞因子白细胞介素-10（IL-10）水平。总的来说，这些发现提示了一种预防老年女性不良妊娠结局的潜在治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6291/11809324/70fab341c36a/ADVS-12-2411613-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6291/11809324/413610bca480/ADVS-12-2411613-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6291/11809324/e7763726ac3e/ADVS-12-2411613-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6291/11809324/59c073cbfe68/ADVS-12-2411613-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6291/11809324/3db441c9a8e5/ADVS-12-2411613-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6291/11809324/61c04192d799/ADVS-12-2411613-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6291/11809324/c68e66d00e6d/ADVS-12-2411613-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6291/11809324/70fab341c36a/ADVS-12-2411613-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6291/11809324/413610bca480/ADVS-12-2411613-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6291/11809324/e7763726ac3e/ADVS-12-2411613-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6291/11809324/59c073cbfe68/ADVS-12-2411613-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6291/11809324/3db441c9a8e5/ADVS-12-2411613-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6291/11809324/61c04192d799/ADVS-12-2411613-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6291/11809324/c68e66d00e6d/ADVS-12-2411613-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6291/11809324/70fab341c36a/ADVS-12-2411613-g002.jpg

相似文献

1
PD-1-Enhanced Treg Cell Senescence in Advanced Maternal Age.高龄产妇中PD-1增强的调节性T细胞衰老
Adv Sci (Weinh). 2025 Feb;12(6):e2411613. doi: 10.1002/advs.202411613. Epub 2024 Dec 23.
2
Association between PD-1/PD-L1 and T regulate cells in early recurrent miscarriage.早期复发性流产中PD-1/PD-L1与调节性T细胞之间的关联
Int J Clin Exp Pathol. 2015 Jun 1;8(6):6512-8. eCollection 2015.
3
Intestinal IFN-γ-producing type 1 regulatory T cells coexpress CCR5 and programmed cell death protein 1 and downregulate IL-10 in the inflamed guts of patients with inflammatory bowel disease.肠内 IFN-γ 产生的 1 型调节性 T 细胞共表达 CCR5 和程序性细胞死亡蛋白 1，并在炎症性肠病患者的炎症肠道中下调 IL-10。
J Allergy Clin Immunol. 2018 Nov;142(5):1537-1547.e8. doi: 10.1016/j.jaci.2017.12.984. Epub 2018 Jan 31.
4
DCAF1 regulates Treg senescence via the ROS axis during immunological aging.DCAF1 通过 ROS 轴调控免疫衰老过程中 Treg 的衰老。
J Clin Invest. 2020 Nov 2;130(11):5893-5908. doi: 10.1172/JCI136466.
5
Anti-PD-1 amplifies costimulation in melanoma-infiltrating T1-like Foxp3 regulatory T cells to alleviate local immunosuppression.抗程序性死亡蛋白1（Anti-PD-1）增强黑色素瘤浸润的T1样叉头框蛋白3（Foxp3）调节性T细胞中的共刺激，以减轻局部免疫抑制。
J Immunother Cancer. 2025 Jan 6;13(1):e009435. doi: 10.1136/jitc-2024-009435.
6
PD-1 but not CTLA-4 blockage abrogates the protective effect of regulatory T cells in a pregnancy murine model.PD-1 阻断而非 CTLA-4 阻断可消除调节性 T 细胞在妊娠小鼠模型中的保护作用。
Am J Reprod Immunol. 2009 Nov;62(5):283-92. doi: 10.1111/j.1600-0897.2009.00737.x.
7
High Antigenicity for T Cells Confers Resistance to PD-1 Blockade Therapy via High PD-1 Expression in T Cells.T细胞的高抗原性通过T细胞中高表达的PD-1赋予对PD-1阻断疗法的抗性。
Cancer Sci. 2025 May;116(5):1214-1226. doi: 10.1111/cas.70029. Epub 2025 Feb 27.
8
The altered PD-1/PD-L1 pathway delivers the 'one-two punch' effects to promote the Treg/Th17 imbalance in pre-eclampsia.PD-1/PD-L1 通路的改变会产生“双重打击”效应，促进子痫前期中 Treg/Th17 的失衡。
Cell Mol Immunol. 2018 Jul;15(7):710-723. doi: 10.1038/cmi.2017.70. Epub 2017 Sep 11.
9
Fetal-maternal alignment of regulatory T cells correlates with IL-10 and Bcl-2 upregulation in pregnancy.胎儿与母体调节性 T 细胞的同步化与妊娠中 IL-10 和 Bcl-2 的上调相关。
J Immunol. 2013 Jul 1;191(1):145-53. doi: 10.4049/jimmunol.1203165. Epub 2013 Jun 3.
10
Decidual macrophages derived NO downregulates PD-L1 in trophoblasts leading to decreased Treg cells in recurrent miscarriage.蜕膜巨噬细胞衍生的 NO 下调滋养层细胞中的 PD-L1，导致复发性流产中 Treg 细胞减少。
Front Immunol. 2023 Jul 14;14:1180154. doi: 10.3389/fimmu.2023.1180154. eCollection 2023.

本文引用的文献

1
IL-27/Blimp-1 axis regulates the differentiation and function of Tim-3+ Tregs during early pregnancy.IL-27/Blimp-1 轴调节妊娠早期 Tim-3+Tregs 的分化和功能。
JCI Insight. 2024 Aug 22;9(16):e179233. doi: 10.1172/jci.insight.179233.
2
CD28 T cells in aging and diseases: From biology to assessment and intervention.衰老和疾病中的 CD28 T 细胞：从生物学到评估和干预。
Int Immunopharmacol. 2024 Apr 20;131:111807. doi: 10.1016/j.intimp.2024.111807. Epub 2024 Mar 12.
3
Regulatory T cell adoptive transfer alters uterine immune populations, increasing a novel MHC-II macrophage associated with healthy pregnancy.
调节性 T 细胞过继转移改变了子宫免疫群体，增加了一种与健康妊娠相关的新型 MHC-II 巨噬细胞。
Front Immunol. 2023 Oct 13;14:1256453. doi: 10.3389/fimmu.2023.1256453. eCollection 2023.
4
Single-cell transcriptomics of Treg reveals hallmarks and trajectories of immunological aging.单细胞转录组学揭示了 Treg 免疫衰老的特征和轨迹。
J Leukoc Biol. 2024 Jan 5;115(1):19-35. doi: 10.1093/jleuko/qiad104.
5
Flip a coin: cell senescence at the maternal-fetal interface†.掷硬币：母胎界面的细胞衰老†。
Biol Reprod. 2023 Sep 12;109(3):244-255. doi: 10.1093/biolre/ioad071.
6
PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior.PD-L1/PD-1 检查点通路调节海马神经元兴奋性和学习记忆行为。
Neuron. 2023 Sep 6;111(17):2709-2726.e9. doi: 10.1016/j.neuron.2023.05.022. Epub 2023 Jun 21.
7
Age-related changes in CD4 T and NK cell compartments may contribute to the occurrence of pregnancy loss in advanced maternal age.CD4 T细胞和自然杀伤（NK）细胞区室的年龄相关变化可能导致高龄孕产妇发生流产。
J Reprod Immunol. 2023 Feb;155:103790. doi: 10.1016/j.jri.2022.103790. Epub 2022 Dec 24.
8
T-cell senescence: A crucial player in autoimmune diseases.T细胞衰老：自身免疫性疾病中的关键因素。
Clin Immunol. 2023 Mar;248:109202. doi: 10.1016/j.clim.2022.109202. Epub 2022 Dec 5.
9
Upregulated PD-1 signaling antagonizes glomerular health in aged kidneys and disease.PD-1 信号上调拮抗老年肾脏和疾病中的肾小球健康。
J Clin Invest. 2022 Aug 15;132(16). doi: 10.1172/JCI156250.
10
HLA-DR CD45RA- Tregs and CD28- Treg-like cells: Potential immunologic biomarkers for reproductive aging.HLA-DR CD45RA-Tregs 和 CD28-Treg 样细胞：生殖衰老的潜在免疫生物标志物。
Am J Reprod Immunol. 2023 Jun;89(6):e13591. doi: 10.1111/aji.13591. Epub 2022 Aug 15.