Asseri Ali Alsuheel
Department of Child Health, King Khalid University, Abha, 62529, Saudi Arabia.
Int J Gen Med. 2024 Dec 17;17:6323-6333. doi: 10.2147/IJGM.S503293. eCollection 2024.
Evidence suggests a strong association between vitamin D status and asthma, with individuals exhibiting vitamin D deficiency demonstrating increased prevalence and severity of asthma symptoms. This study aimed to determine the prevalence of vitamin D deficiency among asthmatic children, assess the association between vitamin D status and asthma severity/control, and identify potential predictors of vitamin D deficiency in this population.
This comparative cross-sectional, hospital-based study was conducted at Abha Maternity and Children's Hospital, a tertiary care and teaching institution in southwestern Saudi Arabia, between January 2023 and May 2024.
A total of 331 asthmatic children and 101 non-asthmatic children were analyzed. Children with asthma had significantly lower serum vitamin D levels than those without asthma (21.5 ± 8.8 ng/mL vs 33.3 ± 13.2 ng/mL, p < 0.001). Significantly higher proportions of asthmatic children exhibited vitamin D deficiency (51.1%) and insufficiency (34.7%) compared to non-asthmatic children (19.8% and 29.7%, respectively). Serum vitamin D levels among asthmatic children showed significant negative correlations with age (r = -0.332, p < 0.001), weight (r = -0.292, p < 0.001), height (r = -0.298, p < 0.001), and BMI (r = -0.274, p < 0.001). These findings were further supported by univariate linear regression analysis. Multivariable analysis additionally confirmed age (β = -0.66, p < 0.001) and BMI (β = -0.25, p = 0.05) as independent predictors of vitamin D status, with older age and higher BMI associated with lower vitamin D levels. For each additional year of age, serum vitamin D decreased by an average of 0.66 ng/mL (p < 0.001) and a one-unit increase in BMI was associated with a decrease of 0.25 ng/mL in serum vitamin D (p = 0.05).
This study found a strikingly high prevalence of vitamin D deficiency among asthmatic children in southwestern Saudi Arabia, significantly exceeding rates in controls. These findings underscore the need for widespread vitamin D screening and supplementation in this population, particularly among older, overweight asthmatic children.
有证据表明维生素D状态与哮喘之间存在密切关联，维生素D缺乏的个体哮喘症状的患病率和严重程度增加。本研究旨在确定哮喘儿童中维生素D缺乏的患病率，评估维生素D状态与哮喘严重程度/控制之间的关联，并确定该人群中维生素D缺乏的潜在预测因素。
这项基于医院的比较横断面研究于2023年1月至2024年5月在沙特阿拉伯西南部的三级医疗和教学机构阿卜哈妇幼医院进行。
共分析了331名哮喘儿童和101名非哮喘儿童。哮喘儿童的血清维生素D水平显著低于非哮喘儿童（21.5±8.8 ng/mL对33.3±13.2 ng/mL，p<0.001）。与非哮喘儿童相比（分别为19.8%和29.7%），哮喘儿童中维生素D缺乏（51.1%）和不足（34.7%）的比例显著更高。哮喘儿童的血清维生素D水平与年龄（r=-0.332，p<0.001）、体重（r=-0.292，p<0.001）、身高（r=-0.298，p<0.001）和BMI（r=-0.274，p<0.001）呈显著负相关。单变量线性回归分析进一步支持了这些发现。多变量分析还证实年龄（β=-0.66，p<0.001）和BMI（β=-0.25，p=0.05）是维生素D状态的独立预测因素，年龄越大和BMI越高与维生素D水平越低相关。每增加一岁，血清维生素D平均下降0.66 ng/mL（p<0.001），BMI每增加一个单位，血清维生素D下降0.25 ng/mL（p=0.05）。
本研究发现沙特阿拉伯西南部哮喘儿童中维生素D缺乏的患病率极高，显著超过对照组。这些发现强调了在该人群中，特别是在年龄较大、超重的哮喘儿童中进行广泛的维生素D筛查和补充的必要性。
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