Rahimzadeh Golnar, Rezai Shaghayegh, Valadan Reza, Rezai Raha, Soleimanpour Saman, Vahedi Laleh, Sheidaei Somayeh, Moradi Masoud, Rezai Mohammad Sadegh, Nemati Ebrahim
Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Medical Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Adv Biomed Res. 2024 Oct 28;13:105. doi: 10.4103/abr.abr_341_24. eCollection 2024.
Amid the COVID-19 pandemic, the surge in hospital admissions and widespread use of broad-spectrum antibiotics have heightened the risk of hospital-acquired infections from multidrug-resistant (MDR) organisms, particularly . It is imperative to implement stringent measures to curb the spread of antimicrobial resistance in hospitals and devise robust treatment strategies for patients grappling with such infections. To confront this challenge, a comprehensive study was undertaken to examine MDR extended-spectrum beta-lactamase (MDR-ESBL)-producing isolates from patients with nosocomial infections following the COVID-19 pandemic in Northern Iran.
The current study was conducted as a cross-sectional study. A total of 12,834 samples were collected from patients with healthcare-associated infections at four designated corona centers in Northern Iran, following the COVID-19 pandemic. Antimicrobial resistance was determined using standard broth micro-dilution, while resistance genes were accurately detected using the multiplex PCR method.
The results indicated that meropenem and ciprofloxacin had a resistance rate of 100% and 98.2%, respectively, while piperacillin-tazobactam showed the highest sensitivity rate at 54.4%. The frequency of specific genes, including , and , were found to be 100%, 100%, 99.1%, 99.1%, 91.2%, 80.7%, 64.9%, 44.7%, and 37.7%, respectively.
In the current study, over 50% of MDR-ESBL-producing isolates exhibited resistance to antibiotics. A combination of antibiotics, including piperacillin-tazobactam and colistin, is recommended for treating extensively drug-resistant infections.
在新冠疫情期间，医院住院人数的激增以及广谱抗生素的广泛使用增加了多重耐药（MDR）病原体导致医院获得性感染的风险，尤其是[此处原文缺失具体病原体]。实施严格措施以遏制医院内抗菌药物耐药性的传播并为感染此类病菌的患者制定强有力的治疗策略势在必行。为应对这一挑战，开展了一项全面研究，以检测伊朗北部新冠疫情后医院感染患者中产生超广谱β-内酰胺酶（ESBL）的多重耐药菌（MDR-ESBL）。
本研究为横断面研究。在伊朗北部四个指定的新冠中心，对新冠疫情后医疗保健相关感染患者共采集了12834份样本。采用标准肉汤微量稀释法测定抗菌药物耐药性，同时使用多重聚合酶链反应（PCR）方法准确检测耐药基因。
结果表明，美罗培南和环丙沙星的耐药率分别为100%和98.2%，而哌拉西林-他唑巴坦的敏感率最高，为54.4%。发现包括[此处原文缺失具体基因名称]等特定基因的频率分别为100%、100%、99.1%、99.1%、91.2%、80.7%、64.9%、44.7%和37.7%。
在本研究中，超过50%产生MDR-ESBL的[此处原文缺失具体病菌名称]分离株对抗生素耐药。建议联合使用包括哌拉西林-他唑巴坦和黏菌素在内的抗生素治疗广泛耐药的[此处原文缺失具体病菌名称]感染。
