Rahimzadeh Golnar, Rezai Mohammad S, Farshidi Fereshteh
Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Adv Biomed Res. 2023 Mar 21;12:56. doi: 10.4103/abr.abr_434_22. eCollection 2023.
is one of the most common bacteria in nosocomial infections. Inappropriate usage of antibiotics has led to expanding emergence resistance to as a multidrug-resistant (MDR) strain. Empirical antibiotic therapy is necessary to evaluate the resistant gene pattern of MDR . For this purpose, the present study evaluated the resistance genes pattern of MDR collected from hospitalized patients using a genotypic diagnostic technique. To find evidence related to the study objectives, databases were searched such as Google Scholar, Web of Science, Science Direct, PubMed, and Scopus from 2000 to 2022, with specified keywords in the title and text of the articles. Articles were included based on inclusion and exclusion criteria. The mentioned database displayed 284 articles. After screening, 65 eligible articles were included. The results showed that various b-lactamases genes, aminoglycoside-modifying enzymes (AMEs) genes, and pump-expressing genes are resistance gene patterns in MDR isolates. MDR has significantly become resistant to b-lactams, carbapenems, and aminoglycosides.
是医院感染中最常见的细菌之一。抗生素的不当使用导致作为多重耐药（MDR）菌株的耐药性不断出现。经验性抗生素治疗对于评估MDR的耐药基因模式是必要的。为此，本研究使用基因型诊断技术评估了从住院患者中收集的MDR的耐药基因模式。为了找到与研究目标相关的证据，检索了2000年至2022年的谷歌学术、科学网、科学Direct、PubMed和Scopus等数据库，在文章的标题和文本中使用了特定的关键词。根据纳入和排除标准纳入文章。上述数据库显示了284篇文章。筛选后，纳入了65篇符合条件的文章。结果表明，各种β-内酰胺酶基因、氨基糖苷类修饰酶（AMEs）基因和泵表达基因是MDR分离株中的耐药基因模式。MDR对β-内酰胺类、碳青霉烯类和氨基糖苷类药物已显著耐药。
