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直肠胃肠道间质瘤：一例长期使用伊马替尼治疗的病例报告

Gastrointestinal Stromal Tumor of the Rectum: Report of a Case With Long-Term Imatinib Treatment.

作者信息

Tripathi Madhumita, Purwar Roli, Sinha Richie, Singh Pooja, Pandey Manoj

机构信息

Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND.

Obstetrics and Gynaecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND.

出版信息

Cureus. 2024 Nov 22;16(11):e74269. doi: 10.7759/cureus.74269. eCollection 2024 Nov.

DOI:10.7759/cureus.74269
PMID:39717333
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11663722/
Abstract

Gastrointestinal stromal tumors (GIST) are rare in the rectum. These usually present with symptoms produced by compression of pelvic organs or bleeding. Surgery is the treatment of choice, however, at times the surgery can be mutilating and organ preservation may not be possible. In such cases imatinib can be used. We report a case of rectal GIST that presented with urinary obstruction and obstipation treated with long-term imatinib with very good response and relief of symptoms, which prompted the patient to refuse surgery and resulted in organ preservation.

摘要

胃肠道间质瘤（GIST）在直肠中较为罕见。这些肿瘤通常表现为盆腔器官受压或出血所产生的症状。手术是首选的治疗方法，然而，有时手术可能会造成毁形，且可能无法保留器官。在这种情况下，可以使用伊马替尼。我们报告一例直肠GIST病例，该病例表现为尿路梗阻和便秘，通过长期使用伊马替尼治疗，反应良好且症状缓解，这促使患者拒绝手术并实现了器官保留。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2c6/11663722/f1308b20f115/cureus-0016-00000074269-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2c6/11663722/0a07722a3f86/cureus-0016-00000074269-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2c6/11663722/647399c32915/cureus-0016-00000074269-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2c6/11663722/f779b938dec6/cureus-0016-00000074269-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2c6/11663722/fb55a5289bc4/cureus-0016-00000074269-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2c6/11663722/f1308b20f115/cureus-0016-00000074269-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2c6/11663722/0a07722a3f86/cureus-0016-00000074269-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2c6/11663722/647399c32915/cureus-0016-00000074269-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2c6/11663722/f779b938dec6/cureus-0016-00000074269-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2c6/11663722/fb55a5289bc4/cureus-0016-00000074269-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2c6/11663722/f1308b20f115/cureus-0016-00000074269-i05.jpg

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本文引用的文献

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Efficacy of Trametinib in Neurofibromatosis Type 1-Associated Gastrointestinal Stromal Tumors: A Case Report.曲美替尼治疗1型神经纤维瘤病相关胃肠道间质瘤的疗效：一例报告
JCO Precis Oncol. 2024 Aug;8:e2300649. doi: 10.1200/PO.23.00649.
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GISTs with Gene Fusions: A Clinicopathological, Immunophenotypic, and Molecular Study.伴有基因融合的胃肠道间质瘤：一项临床病理、免疫表型及分子研究
Cancers (Basel). 2022 Dec 23;15(1):105. doi: 10.3390/cancers15010105.
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Long-Term Imatinib Treatment for Patients with Unresectable or Recurrent Gastrointestinal Stromal Tumors.
不可切除或复发性胃肠道间质瘤患者的长期伊马替尼治疗。
Digestion. 2018;97(1):20-25. doi: 10.1159/000484102. Epub 2018 Feb 1.
4
Rectal Gastrointestinal Stromal Tumor (GIST) in the Era of Imatinib: Organ Preservation and Improved Oncologic Outcome.直肠胃肠道间质瘤（GIST）在伊马替尼时代：器官保存和改善的肿瘤学结果。
Ann Surg Oncol. 2017 Dec;24(13):3972-3980. doi: 10.1245/s10434-017-6087-9. Epub 2017 Oct 20.
5
Early Evaluation of Response Using F-FDG PET Influences Management in Gastrointestinal Stromal Tumor Patients Treated with Neoadjuvant Imatinib.使用 F-FDG PET 早期评估反应影响新辅助伊马替尼治疗胃肠道间质瘤患者的治疗管理。
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Epidemiology of gastrointestinal stromal tumors in the era of histology codes: results of a population-based study.组织学编码时代胃肠道间质瘤的流行病学：一项基于人群研究的结果
Cancer Epidemiol Biomarkers Prev. 2015 Jan;24(1):298-302. doi: 10.1158/1055-9965.EPI-14-1002. Epub 2014 Oct 2.
7
Consensus report on the radiological management of patients with gastrointestinal stromal tumours (GIST): recommendations of the German GIST Imaging Working Group.胃肠道间质瘤（GIST）患者放射学管理的共识报告：德国 GIST 成像工作组的建议。
Cancer Imaging. 2012 May 7;12(1):126-35. doi: 10.1102/1470-7330.2012.0013.
8
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido.伊马替尼通过抑制 IDO 增强胃肠道间质瘤中的抗肿瘤 T 细胞反应。
Nat Med. 2011 Aug 28;17(9):1094-100. doi: 10.1038/nm.2438.
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Gastrointestinal stromal tumors: molecular mechanisms and targeted therapies.胃肠道间质瘤：分子机制与靶向治疗
Patholog Res Int. 2011 Apr 14;2011:708596. doi: 10.4061/2011/708596.
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NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors.NCCN 工作组报告：胃肠道间质瘤患者管理的最新进展。
J Natl Compr Canc Netw. 2010 Apr;8 Suppl 2(0 2):S1-41; quiz S42-4. doi: 10.6004/jnccn.2010.0116.