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直肠胃肠道间质瘤:一例长期使用伊马替尼治疗的病例报告

Gastrointestinal Stromal Tumor of the Rectum: Report of a Case With Long-Term Imatinib Treatment.

作者信息

Tripathi Madhumita, Purwar Roli, Sinha Richie, Singh Pooja, Pandey Manoj

机构信息

Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND.

Obstetrics and Gynaecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND.

出版信息

Cureus. 2024 Nov 22;16(11):e74269. doi: 10.7759/cureus.74269. eCollection 2024 Nov.

Abstract

Gastrointestinal stromal tumors (GIST) are rare in the rectum. These usually present with symptoms produced by compression of pelvic organs or bleeding. Surgery is the treatment of choice, however, at times the surgery can be mutilating and organ preservation may not be possible. In such cases imatinib can be used. We report a case of rectal GIST that presented with urinary obstruction and obstipation treated with long-term imatinib with very good response and relief of symptoms, which prompted the patient to refuse surgery and resulted in organ preservation.

摘要

胃肠道间质瘤(GIST)在直肠中较为罕见。这些肿瘤通常表现为盆腔器官受压或出血所产生的症状。手术是首选的治疗方法,然而,有时手术可能会造成毁形,且可能无法保留器官。在这种情况下,可以使用伊马替尼。我们报告一例直肠GIST病例,该病例表现为尿路梗阻和便秘,通过长期使用伊马替尼治疗,反应良好且症状缓解,这促使患者拒绝手术并实现了器官保留。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2c6/11663722/0a07722a3f86/cureus-0016-00000074269-i01.jpg

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